Cucurbitacin B
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects... more
Product information "Cucurbitacin B"
Description: Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung Y cells. Target: PTEN, Autophagy, HIF, Integrin, Apoptosis, Endogenous Metabolite, STAT. Smiles: CC(=O)OC(C)(C)C=CC(=O)C(C)(O)C1C(O)CC2(C)C3CC=C4C(CC(O)C(=O)C4(C)C)C3(C)C(=O)CC12C. References: Yin D, et al. Int J Cancer. 2008, 123(6), 1364-1375.
| Keywords: | DATISCACIN, Cuc B, Amarine |
| Supplier: | TargetMol |
| Supplier-Nr: | T3404 |
Properties
| Application: | Microtubule polymerization inhibitor |
| MW: | 558.7 D |
| Formula: | C32H46O8 |
Database Information
| CAS : | 6199-67-3| Matching products |
| KEGG ID : | K07374 | Matching products |
Handling & Safety
| Storage: | +4°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H300 |
| P Phrases: | P264, P270, P301+310, P321, P330, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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