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Cyclin-dependent kinases (Cdks) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. Cdk1/5 Inhibitor is a pyrazolo [3,4-b] quioxaline that inhibits Cdk1/cyclin B and Cdk5/p25 (IC50s = 600 and 400 nM, respectively). It less potently inhibits GSK3beta (IC50 = 1 µM) and does not block Cdc25 activity. This compound is used to help define the roles of Cdk1 and Cdk5 in various signaling pathways.Formal Name: 1H-pyrazolo[3,4-b]quinoxalin-3-amine. CAS Number: 40254-90-8. Synonyms: Cyclin-dependent kinase 1/5 Inhibitor, NSC 693868. Molecular Formula: C9H7N5. Formula Weight: 185.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMSO: 5 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 254, 334 nm. SMILES: NC1=NNC2=NC3=C(N=C21)C=CC=C3. InChi Code: InChI=1S/C9H7N5/c10-8-7-9(14-13-8)12-6-4-2-1-3-5(6)11-7/h1-4H,(H3,10,12,13,14). InChi Key: DWHVZCLBMTZRQM-UHFFFAOYSA-N.
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