CAY10771

CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor delta (PPARdelta). It activates FXR and PPARdelta in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 µM, respectively) and is selective for these receptors over retinoic acid receptor alpha (RARalpha), retinoid X receptor alpha (RXRalpha), PPARalpha, PPARgamma, and liver X receptor alpha (LXRalpha) at 10 µM.Formal Name: 4-[[[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]methyl]amino]-benzeneacetic acid. CAS Number: 2522599-79-5. Molecular Formula: C28H25Cl3N2O4. Formula Weight: 559.9. Purity: >98%. Formulation: (Request formulation change), A solution in acetonitrile. Solubility: Acetonitrile: 5 mg/ml. SMILES: ClC1=CC=CC(Cl)=C1C2=NOC(C(C)C)=C2COC3=CC(Cl)=C(CNC4=CC=C(CC(O)=O)C=C4)C=C3. InChi Code: InChI=1S/C28H25Cl3N2O4/c1-16(2)28-21(27(33-37-28)26-22(29)4-3-5-23(26)30)15-36-20-11-8-18(24(31)13-20)14-32-19-9-6-17(7-10-19)12-25(34)35/h3-11,13,16,32H,12,14-15H2,1-2H3,(H,34,35). InChi Key: SPZFHDGEKBUECT-UHFFFAOYSA-N.