CAY10722

CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 µM). SIRT3 is involved in modulating metabolic homeostasis as a NAD+-dependent protein deacetylase in the mitochondria. SIRT3 functions as either an oncogene or tumor suppressor, depending on cancer cell type. High SIRT3 expression in patient-derived esophageal cancer tissues is associated with shorter survival and, in mice, downregulation leads to a lower tumor load. In contrast, low SIRT3 expression in patient-derived breast cancer cells is correlated with shorter survival.Formal Name: N-[2-(2,4-dichlorophenyl)-5-benzoxazolyl]-benzeneacetamide. CAS Number: 388086-13-3. Molecular Formula: C21H14Cl2N2O2. Formula Weight: 397.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: Slightly soluble. lambdamax: 211, 242, 315 nm. SMILES: ClC(C=C(Cl)C=C1)=C1C2=NC3=CC(NC(CC4=CC=CC=C4)=O)=CC=C3O2. InChi Code: InChI=1S/C21H14Cl2N2O2/c22-14-6-8-16(17(23)11-14)21-25-18-12-15(7-9-19(18)27-21)24-20(26)10-13-4-2-1-3-5-13/h1-9,11-12H,10H2,(H,24,26). InChi Key: HUGVXMJZAPFVHU-UHFFFAOYSA-N.