CAY10719

CAY10719 is a selective inhibitor of the breast cancer resistance protein ABCG2 (IC50 = 0.23 µM) with little activity at ABCG1. It has been shown to reverse the ABCG2-mediated resistance toward SN 38 (Cay-15632) and to inhibit ATPase activity.Formal Name: [1-(3,4-dichlorophenyl)-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl](4-methoxyphenyl)-methanone. CAS Number: 1942919-63-2. Molecular Formula: C25H20Cl2N2O2. Formula Weight: 451.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS(pH7.2) (1:2): 0.33 mg/ml, DMSO: 2 mg/ml. lambdamax: 225 nm. SMILES: COC1=CC=C(C(N2C(C3=CC(Cl)=C(Cl)C=C3)C(NC4=C5C=CC=C4)=C5CC2)=O)C=C1. InChi Code: InChI=1S/C25H20Cl2N2O2/c1-31-17-9-6-15(7-10-17)25(30)29-13-12-19-18-4-2-3-5-22(18)28-23(19)24(29)16-8-11-20(26)21(27)14-16/h2-11,14,24,28H,12-13H2,1H3. InChi Key: AKQFVWUCZTWDKB-UHFFFAOYSA-N.