CA 074

Description: CA 074 is a potent inhibitor of cathepsin B with a Ki value of 2 to 5 nM.CA 074 inhibits ischemic hippocampal neuronal death in primates and attenuates retinopathy and optic neuritis in experimental autoimmune encephalomyelitis induced by SJL/J mice. Target: Cysteine Protease. Smiles: [H][C@](NC(=O)[C@H]1O[C@@H]1C(=O)NCCC)([C@@H](C)CC)C(=O)N1CCC[C@H]1C(O)=O. References: Yamashima T, et al. Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA-074: a novel strategy for neuroprotection based on 'calpain-cathepsin hypothesis'. Eur J Neurosci. 1998 May,10(5):1723-33.