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Arcyriaflavin A is an inhibitor of cyclin-dependent kinase 4 (CDK4, IC50 = 140 nM) and calcium/calmodulin-dependent protein kinase II (CaMKII, IC50 = 25 nM). It is selective for CDK4 and CaMKII over protein kinase A (PKA) and PKC (IC50s = >2 and >100 µM, respectively). In vitro, arcyriaflavin A inhibits replication of human cytomegalovirus (HCMV, IC50 = 200 nM), as well as proliferation of HCT116 and NCI H460 human carcinoma cells (IC50s = 850 and 590 nM, respectively). It also inhibits proliferation and induces apoptosis of endometriotic cyst stromal cells (ECSCs).Formal Name: 12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione. CAS Number: 118458-54-1. Molecular Formula: C20H11N3O2. Formula Weight: 325.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml, DMSO: 1 mg/ml. lambdamax: 235, 281, 315 nm. SMILES: O=C1NC(C2=C1C(C3=CC=CC=C3N4)=C4C5=C2C6=C(C=CC=C6)N5)=O. InChi Code: InChI=1S/C20H11N3O2/c24-19-15-13-9-5-1-3-7-11(9)21-17(13)18-14(16(15)20(25)23-19)10-6-2-4-8-12(10)22-18/h1-8,21-22H,(H,23,24,25). InChi Key: KAJXOWFGKYKMMZ-UHFFFAOYSA-N.
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