Ambroxol (hydrochloride)

Ambroxol is an expectorant and active metabolite of bromhexine. It decreases short-circuit currents in electrically stimulated isolated canine tracheal epithelial cells when applied submucosally (IC50 = 60 nM). It inhibits the voltage-gated sodium channel Nav1.2 in isolated dorsal root neurons (IC50 = 110 µM for the rat channel). Ambroxol (100 µM) decreases IL-13-induced production of mucin 5AC (MUC5AC) in primary human airway epithelial cells and inhibits IL-13-induced decreases in the mucociliary transport rate of endogenous particles in the same cells. Ambroxol increases phenol red secretion, a marker of expectorant activity, in mice when administered at doses of 30, 60, or 120 mg/kg. Formulations containing ambroxol have been used in the treatment of acute or chronic respiratory conditions.Formal Name: trans-4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-cyclohexanol, monohydrochloride. CAS Number: 23828-92-4. Synonyms: NA 872. Molecular Formula: C13H18Br2N2O . HCl. Formula Weight: 414.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: Slightly soluble. lambdamax: 212, 249, 317 nm. SMILES: BrC1=CC(Br)=CC(CN[C@@H]2CC[C@@H](O)CC2)=C1N.Cl. InChi Code: InChI=1S/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10,/h5-6,10-11,17-18H,1-4,7,16H2,1H/t10-,11-,. InChi Key: QNVKOSLOVOTXKF-PFWPSKEQSA-N.