ALX 5407 (hydrochloride)

ALX 5407 is an inhibitor of glycine transporter 1 (GlyT1, IC50 = 3 nM). It is selective for GlyT1 over GlyT2 (IC50 = >10 µM), as well as over NMDA receptors and the inhibitory glycine receptor at 100 µM. ALX 5407 (10 mg/kg) increases prefrontal cortical levels of glycine in rats. It also reverses MK-801-induced persistent latent inhibition in a mouse model of schizophrenia.Formal Name: N-[(3R)-3-([1,1'-biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methyl-glycine, monohydrochloride. CAS Number: 200006-08-2. Molecular Formula: C24H24FNO3 . HCl. Formula Weight: 429.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 20 mg/ml. SMILES: FC(C=C1)=CC=C1[C@@H](CCN(C)CC(O)=O)OC(C=C2)=CC=C2C3=CC=CC=C3.Cl. InChi Code: InChI=1S/C24H24FNO3.ClH/c1-26(17-24(27)28)16-15-23(20-7-11-21(25)12-8-20)29-22-13-9-19(10-14-22)18-5-3-2-4-6-18,/h2-14,23H,15-17H2,1H3,(H,27,28),1H/t23-,/m1./s1. InChi Key: RPDGSZCYSJWQEE-GNAFDRTKSA-N.