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A-438079 is a competitive antagonist of the nucleotide receptor P2X7 (pIC50 = 6.9). It inhibits both calcium flux and IL-1beta release mediated by P2X7 while not affecting the activity of other P2X receptors. A-438079 is effective in evaluating the role of P2X7 in nociception, oxidative stress, and apoptosis in cells and animals.Formal Name: 3-[[5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl]methyl]-pyridine, monohydrochloride. CAS Number: 899431-18-6. Molecular Formula: C13H9Cl2N5 . HCl. Formula Weight: 342.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.33 mg/ml, Ethanol: 10 mg/ml. SMILES: ClC1=C(Cl)C=CC=C1C2=NN=NN2CC3=CN=CC=C3.Cl. InChi Code: InChI=1S/C13H9Cl2N5.ClH/c14-11-5-1-4-10(12(11)15)13-17-18-19-20(13)8-9-3-2-6-16-7-9,/h1-7H,8H2,1H. InChi Key: MBTJFFMIPPMRGR-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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