(±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (hydrobromide)

(±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (6,7-ADTN) is a dopamine receptor agonist (EC50s = 3.5 and 0.65 µM in rat striatal and nucleus accumbens homogenates, respectively). 6,7-ADTN stimulates production of cAMP in rat striatal homogenates, a process that is reduced by 70% in the presence of the dopamine antagonist fluphenazine (Cay-23555) at a concentration of 1 µM. In vivo, 6,7-ADTN induces hyperlocomotion in rats when injected bilaterally at a dose of 100 nmol per side into the nucleus accumbens. It increases cAMP production and glycoprotein secretion in the albumen gland of H. duryi (snail). It also reduces sucrose feeding in R. maderae (cockroach) nymphs.Formal Name: 6-amino-5,6,7,8-tetrahydro-2,3-naphthalenediol, monohydrobromide. CAS Number: 13575-86-5. Synonyms: (±)-ADTN, 6,7-ADTN, 6,7-diOHATN, NSC 287353. Molecular Formula: C10H13NO2 . HBr. Formula Weight: 260.1. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: 100 mM. SMILES: NC1CCC2=CC(O)=C(O)C=C2C1.Br. InChi Code: InChI=1S/C10H13NO2.BrH/c11-8-2-1-6-4-9(12)10(13)5-7(6)3-8,/h4-5,8,12-13H,1-3,11H2,1H. InChi Key: ZGHHIOBQEXZBAG-UHFFFAOYSA-N.