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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
BPS-82238 | 2 vials | - | - |
3 - 15 business days* |
8,560.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
ADAR1 Responsive Luciferase Reporter HEK293 Cell Line is a HEK293 cell line designed to respond... more
Product information "ADAR1 Responsive Luciferase Reporter HEK293 Cell Line"
ADAR1 Responsive Luciferase Reporter HEK293 Cell Line is a HEK293 cell line designed to respond to ADAR1 enzymatic activity. These cells were engineered to express an ADAR1 reporter construct comprised of an ADAR1 hairpin target with a stop codon (UAG) susceptible to ADAR1-mediated editing to tryptophan (UUG), located upstream of a firefly luciferase reporter (Figure 1). This cell line has been validated by comparing reporter activation after transfection with ADAR1 and ADAR2. This cell line has been used for the development of the constitutive ADAR1 expressing ADAR1 Activity Luciferase Reporter HEK293 Cell Line (#82239). The ADAR1 reporter construct is compromised of an ADAR1 hairpin targer with a stop codon (UAG) upstream of the sequence encoding luciferase. In the presence of ADAR1 activity, as in the case of transfection with ADAR1, adenine is converted into inosine encoding now the amino acid tryptophan (UUG) and enabling transcription and expression of luciferase. In the absence of transfected ADAR1, luciferase is not transcribed, and the cells show background luciferase activity. Luciferase activity directly correlated with ADAR1 activity.
Keywords: | p136, ADAR, DRADA, IFI-4, ADAR1, K88DSRBP, Interferon-inducible protein 4, 136 kDa double-stranded RNA-binding protein, Double-stranded RNA-specific adenosine deaminase, |
Supplier: | BPS Bioscience |
Supplier-Nr: | 82238 |
Properties
Application: | ADAR1 activity monitoring |
Species reactivity: | human |
Database Information
KEGG ID : | K12968 | Matching products |
UniProt ID : | P55265 | Matching products |
Gene ID | GeneID 103 | Matching products |
Handling & Safety
Storage: | Liquid nitrogen |
Shipping: | -80°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
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