Human VDR (Vitamin D Receptor) ELISA Kit

The kit is a Sandwich enzyme immunoassay for in vitro quantitative measurement of VDR in serum, plasma and other biological fluids. Detection Range: 0.63--40ng/mL. Sensitivity: 0.38ng/mL. Protein function: Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis. [The UniProt Consortium]