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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| G-CAB20365.20 | 20 µl | - |
9 - 20 business days* |
149.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Dioxygenase that catalyzes the conversion of the modified genomic base... more
Product information "Anti-TET2"
Protein function: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. [The UniProt Consortium]
| Keywords: | Anti-Tet2, Anti-Kiaa1546, Anti-Protein Ayu17-449, Anti-Methylcytosine dioxygenase TET2 |
| Supplier: | Assay Genie |
| Supplier-Nr: | CAB20365 |
Properties
| Application: | WB, IF |
| Conjugate: | No |
| Host: | Rabbit |
| Species reactivity: | human, mouse, rat |
Database Information
| KEGG ID : | K24309 | Matching products |
| UniProt ID : | Q4JK59 | Matching products |
| Gene ID | GeneID 214133 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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