Anti-Stratifin/SFN (Epithelial cell marker protein 1, Stratifin)

Stratifin(SFN), also known as 14-3-3 protein sigma, is strongly induced by gamma irradiation and other , DNA-damaging agents. The induction of 14-3-3-sigma is mediated by a p53 -responsive element located , 1.8 kb upstream of its transcription start site. Leffers et al. (1993)obtained peptide sequence and , subsequently cloned a T-cell cDNA of the 14-3-3 family of conserved proteins. The protein, called , stratifin, was shown to be diffusely distributed in the cytoplasm and was present in cultured epithelial , cells. It was most abundant in tissues enriched in stratified keratinizing epithelium. UniProt Number: P31947, Gene ID: SFN, Applications: Suitable for use in Western Blot, Immunohistochemistry (Paraffin) and Immunocytochemistry. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Handling: Store at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term., Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.