Anti-Shugoshin 2 / SGO2 / SGOL2

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Shugoshin 2 (SGO2), also called Shugoshin-like 2 (SGOL2), is predicted to be involved in homologous chromosome segregation, meiotic sister chromatid cohesion, and mitotic sister chromatid segregation. Predicted to act upstream of or within meiotic nuclear division, positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric, and protein localization. Located in chromosome, centromeric region and nuclear body. Part of mitotic cohesion complex. Protein function: Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation. Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. [The UniProt Consortium]