Anti-RIPK1 / RIP1

Anti-RIPK1 / RIP1
Anti-RIPK1 / RIP1
Anti-RIPK1 / RIP1
Anti-RIPK1 / RIP1
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Item number Size Datasheet Manual SDS Delivery time Quantity Discount Price
ARG40183.100 100 µl - -

6 - 14 business days*

30 %
624.00€
436.80€
 
Protein function: Serine-threonine kinase which transduces inflammatory and cell-death signals... more
Product information "Anti-RIPK1 / RIP1"
Protein function: Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage (PubMed:11101870, PubMed:17389591, PubMed:19524512, PubMed:19524513). Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor (PubMed:11101870, PubMed:17389591, PubMed:19524512, PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF- alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:17389591). Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules (PubMed:15258597). Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death (PubMed:15258597). RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex (PubMed:19524513, PubMed:19524512). [The UniProt Consortium]
Keywords: Anti-RIP, Anti-RIP-1, Anti-RIPK1, Anti-Cell death protein RIP, Anti-Receptor-interacting protein 1, Anti-Receptor-interacting serine/threonine-protein kinase 1
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG40183

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: Recombinant fusion protein corresponding to aa. 170-440 of Human RIPK1 (NP_003795.2)
MW: 75 kD
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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