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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
MON-MON7069 | 1 ml | - | - |
Request delivery time estimate |
471.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
MON7069 reacts with human proteinase 3 (PR3), a 30 kDa protein. PR3 is a major antigen recognized... more
Product information "Anti-PR3, clone PR3G-2 (Monoclonal) [Mouse]"
MON7069 reacts with human proteinase 3 (PR3), a 30 kDa protein. PR3 is a major antigen recognized by autoantibodies directed against cytoplasmic proteins of neutrophilic granulocytes and monocytes (called anti-neutrophil cytoplasmic autoantibodies (ANCA)). ANCA are able to activate primed neutrophils to produce oxygen radicals and release lytic enzymes, including PR3. Proteinase 3 (PR3) was identified as the target antigen of ANCA in Wegener's granulomatosis (WG). ANCA directed against PR3 (PR3-ANCA) can interfere with the binding of PR3 to its physiological inhibitor alpha1-antitrypsin (alpha1-AT) and with the proteolytic activity of PR3. At the site of inflammation, PR3 can cleave the PR3- ANCA complex between these inhibiting ANCA and PR3 itself, leaving active PR3. Autoantibodies to PR3 are potent activators of the 5-lipoxygenase pathway in primed human neutrophils. Extracellular free arachidonic acid, as present at an inflammatory focus, synergizes with such autoantibodies to evoke full-blown lipid mediator generation, granule secretion and respiratory burst. Proteinase 3 (PR3) is a neutral serine proteinase, which is localized in the azurophilic granules of neutrophils and in granules of monocytes and can be detected in the membrane of secretory vesicles. PR3 degrades a number of extracellular matrix proteins such as elastin and inactivates human C1 inhibitor. Protein function: Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279). [The UniProt Consortium]
Keywords: | Anti-MBN, Anti-PR3, Anti-P29, Anti-PR-3, Anti-AGP7, Anti-NP-4, Anti-PRTN3, Anti-Myeloblastin, Anti-C-ANCA antigen, Anti-Wegener autoantigen, Anti-Leukocyte proteinase 3, Anti-Neutrophil proteinase 4, Mouse anti-PR3, clone PR3G-2 (Monoclonal) |
Supplier: | MONOSAN |
Supplier-Nr: | MON7069 |
Properties
Application: | FC, IHC, IP, WB |
Antibody Type: | Monoclonal |
Clone: | PRG-2 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Database Information
KEGG ID : | K01350 | Matching products |
UniProt ID : | P24158 | Matching products |
Gene ID | GeneID 5657 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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