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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-RQ8106 | 100 µg | - | - |
3 - 10 business days* |
755.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Serine/threonine-protein phosphatase 4... more
Product information "Anti-PPP4C / PP-X"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Serine/threonine-protein phosphatase 4 catalytic subunit, also called Protein phosphatase X (PP-X), is an enzyme that in humans is encoded by the PPP4C gene. Enables protein serine/threonine phosphatase activity. Involved in regulation of double-strand break repair via homologous recombination. Located in cytosol, nucleoplasm, and plasma membrane. Protein function: Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2- PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase. In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin. [The UniProt Consortium]
Keywords: | Anti-Pp4, Anti-PP4C, Anti-PPP4, Anti-PP-X, Anti-PPP4C, Anti-Protein phosphatase X, Anti-Serine/threonine-protein phosphatase 4 catalytic subunit, PPP4C Antibody / PP-X |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | RQ8106 |
Properties
Application: | WB, IHC (paraffin), IF, FC, Direct ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | E. coli-derived recombinant human protein (amino acids Q13-L307) |
Format: | Purified |
Database Information
KEGG ID : | K15423 | Matching products |
UniProt ID : | P60510 | Matching products |
Gene ID | GeneID 5531 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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