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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-10-7552-25 | 25 µg | - |
3 - 11 business days* |
149.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Parathyroid hormone (PTH) produced and secreted by parathyroid glands, maintains mineral... more
Product information "Anti-Parathyroid Hormone (Clone: ABM4D44)"
Parathyroid hormone (PTH) produced and secreted by parathyroid glands, maintains mineral homeostasis by regulating calcium and phosphate absorption/reabsorption. It modulates phosphate homeostasis by downregulating Dentin matrix acidic phosphoprotein 1(DMP1) expression via the cAMP/PKA pathway targeting genes/proteins mutually governed by PTH. PTH secretion is characterized by an ultradian rhythm with tonic and pulsatile components. The majority of PTH is secreted in tonic fashion. Changes in the ultradian PTH secretion are correlated with skeletal fragility in primary and secondary osteoporosis. Plasma concentrations of Zn ions levels were significantly correlated with PTH levels. PTH in serum is typical for patients with chronic kidney disease (CKD). The onset of CKD is associated with pathway changes of protein synthesis and metabolism, amino acid metabolism, energy metabolism, and steroid hormone metabolism. Parathyroid hormones are bone-forming agents that have different modes of action on the bone. Lack of PTH in the central nervous system causes Hypoparathyroidism (HPT). Protein function: Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. [The UniProt Consortium]
Keywords: | Anti-PTHR, Anti-PTH1R, Anti-PTH1 receptor, Anti-PTH/PTHr receptor, Anti-PTH/PTHrP type I receptor, Anti-Parathyroid hormone 1 receptor, Anti-Parathyroid hormone/parathyroid hormone-related peptide receptor, Monoclonal Antibody to Parathyroid Hormone (Clon |
Supplier: | Abeomics |
Supplier-Nr: | 10-7552-25 |
Properties
Application: | IHC, WB |
Antibody Type: | Monoclonal |
Clone: | ABM4D44 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | A partial length recombinant Parathyroid Hormone protein (amino acids 1-236) was used as the immunogen for this antibody |
Format: | Purified |
Database Information
KEGG ID : | K04585 | Matching products |
UniProt ID : | Q03431 | Matching products |
Gene ID | GeneID 5745 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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