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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-F50895-0.08ML | 80 µl | - | - |
3 - 10 business days* |
326.00€
|
||
NSJ-F50895-0.4ML | 400 µl | - | - |
3 - 10 business days* |
702.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
In 1X PBS, pH 7.4, with 0.09% sodium azide. The PAK6 protein shares a high degree of sequence... more
Product information "Anti-PAK6"
In 1X PBS, pH 7.4, with 0.09% sodium azide. The PAK6 protein shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. PAK6 was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen. Protein function: Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. [The UniProt Consortium]
Keywords: | Anti-PAK5, Anti-PAK6, Anti-PAK-6, Anti-PAK-5, EC=2.7.11.1, Anti-p21-activated kinase 6, Anti-Serine/threonine-protein kinase PAK 6, PAK6 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | F50895 |
Properties
Application: | WB, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | A portion of amino acids 116-146 from the human protein was used as the immunogen for this PAK6 antibody. |
Format: | Purified |
Database Information
KEGG ID : | K05735 | Matching products |
UniProt ID : | Q9NQU5 | Matching products |
Gene ID | GeneID 106821730 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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