Anti-Osteoprotegerin/TNFRSF11B (Detector), clone 7D9

Anti-Osteoprotegerin/TNFRSF11B (Detector), clone 7D9
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AN001770P.25 25 µg - -

7 - 16 business days*

129.00€
E-AN001770P.100 100 µg - -

7 - 16 business days*

346.00€
E-AN001770P.1 1 mg - -

7 - 16 business days*

1,396.00€
 
TNFRSF11B is a secreted protein, containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is... more
Product information "Anti-Osteoprotegerin/TNFRSF11B (Detector), clone 7D9"
TNFRSF11B is a secreted protein, containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL, TNFRSF11B inhibits nuclear kappa B (NF-kappaB) which is a central and rapid acting transcription factor for immune-related genes, and a key regulator of inflammation, innate immunity, and cell survival and differentiation. TNFRSF11B levels are influenced by voltage-dependent calcium channelsCav1.2. TNFRSF11B can reduce the production of osteoclasts by inhibiting the differentiation of osteoclast precursors (osteoclasts are related to monocytes/macrophages and are derived from granulocyte/macrophage-forming colony units (CFU-GM)) into osteoclasts and also regulates the resorption of osteoclasts in vitroand in vivo. TNFRSF11B binding to RANKL on osteoblast/stromal cells, blocks the RANKL-RANK ligand interaction between Protein function: Acts as a decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. [The UniProt Consortium]
Keywords: Anti-OCIF, Anti-TNFRSF11B, Anti-Osteoprotegerin, Anti-Osteoclastogenesis inhibitory factor, Anti-Tumor necrosis factor receptor superfamily member 11B, Osteoprotegerin/TNFRSF11B Monoclonal Antibody(Detector)
Supplier: Elabscience
Supplier-Nr: E-AN001770P

Properties

Application: ELISA Detector
Antibody Type: Monoclonal
Clone: 7D9
Conjugate: No
Host: Rat
Species reactivity: human
Immunogen: Recombinant Human Osteoprotegerin/TNFRSF11B protein expressed by Mammalian

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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