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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-43-1074-100 | 100 µg | - |
3 - 11 business days* |
478.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The J43.1 monoclonal antibody specifically reacts with mouse CD279, also known as PD-1... more
Product information "Anti-Mouse CD279 (PD-1) NALE(TM) Purified (Clone: J43.1)"
The J43.1 monoclonal antibody specifically reacts with mouse CD279, also known as PD-1 (programmed death-1), a 50-55 kDa glycoprotein of the Ig superfamily. The PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-H2) are members of the B7 family. Pd-1 contains an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM) and influences the peripheral tolerances and autoimmune diseases in mice. PD-1 is transiently expressed on CD4/CD8 thymocytes, it is upregulated in apoptotic cells, and it is expressed by activated myeloid and T and B cells. The binding of PD-1 to its ligands is blocked by the J43 antibody, which also enhances contact hypersensitivity and exacerbates acute Graft-versus-host disease, Experimental autoimmune encephalomyelitis and NOD diabetes. PD-1 seems to downregulate the immune response, as the development of splenomegaly and breakdown of peripheral tolerance in PD-1 deficient mice suggests. Protein function: Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen- specific manner. Possible cell death inducer, in association with other factors. [The UniProt Consortium]
Keywords: | Anti-Pd1, Anti-mPD-1, Anti-Pdcd1, Anti-CD279, Anti-Protein PD-1, Anti-Programmed cell death protein 1, Monoclonal Antibody to Mouse CD279 (PD-1) NALE(TM) Purified (Clone: J43.1) |
Supplier: | Abeomics |
Supplier-Nr: | 43-1074 |
Properties
Application: | IP |
Antibody Type: | Monoclonal |
Clone: | J43.1 |
Conjugate: | No |
Host: | Armenian Hamster |
Species reactivity: | mouse |
Format: | Affinity Purified |
Database Information
KEGG ID : | K06744 | Matching products |
UniProt ID : | Q02242 | Matching products |
Gene ID | GeneID 18566 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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