Anti-LAG3 antibody(DM160), Rabbit mAb

Anti-LAG3 antibody(DM160), Rabbit mAb
Item number Size Datasheet Manual SDS Delivery time Quantity Price
DIM-DME100160.10 10 µg - -

7 - 16 business days*

139.00€
DIM-DME100160.100 100 µg - -

7 - 16 business days*

624.00€
DIM-DME100160.500 500 µg - -

7 - 16 business days*

1,876.00€
 
Protein function: Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated... more
Product information "Anti-LAG3 antibody(DM160), Rabbit mAb"
Protein function: Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648). Delivers inhibitory signals upon binding to ligands, such as FGL1. FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function. Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1. Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648). Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function. Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation. Binds MHC class II (MHC-II), the precise role of MHC-II-binding is however unclear (PubMed:8647185). [The UniProt Consortium]
Keywords: Anti-LAG-3, Anti-CD223, Anti-LAG3 antibody(DM160), Rabbit mAb
Supplier: DIMA
Supplier-Nr: DME100160

Properties

Antibody Type: Monoclonal
Clone: DM160
Conjugate: No
Host: Rabbit
Species reactivity: human
Format: Lyophilized

Database Information

CAS : 12| Matching products
UniProt ID : P18627 | Matching products

Handling & Safety

Storage: -20°C (avoid repeat freezing and thawing cycles)
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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