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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ATA-HPA047001.100 | 100 µl | - |
7 - 10 business days* |
446.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Component of the general transcription and DNA repair factor IIH (TFIIH) core... more
Product information "Anti-GTF2H2"
Protein function: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 97% and to rat: 96%
Keywords: | Anti-GTF2H2, Anti-BTF2P44, Anti-BTF2 p44, Anti-General transcription factor IIH subunit 2, Anti-Basic transcription factor 2 44 kDa subunit, Anti-General transcription factor IIH polypeptide 2, Anti-TFIIH basal transcription factor complex p44 subunit |
Supplier: | Atlas Antibodies |
Supplier-Nr: | HPA047001 |
Properties
Application: | ICC, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: HVSPPPASSS SECSLIRMGF PQHTIASLSD QDAKPSFSMA HLDGNTEPGL TLGGYFCPQC RAKYCELPVE CKICG (ATA-APrEST89535) |
Database Information
KEGG ID : | K03142 | Matching products |
UniProt ID : | Q13888 | Matching products |
Gene ID | GeneID 2966 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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