Anti-GTF2H2

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ATA-HPA047001.100 100 µl -

7 - 10 business days*

446.00€
 
Protein function: Component of the general transcription and DNA repair factor IIH (TFIIH) core... more
Product information "Anti-GTF2H2"
Protein function: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 97% and to rat: 96%
Keywords: Anti-GTF2H2, Anti-BTF2P44, Anti-BTF2 p44, Anti-General transcription factor IIH subunit 2, Anti-Basic transcription factor 2 44 kDa subunit, Anti-General transcription factor IIH polypeptide 2, Anti-TFIIH basal transcription factor complex p44 subunit
Supplier: Atlas Antibodies
Supplier-Nr: HPA047001

Properties

Application: ICC, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: HVSPPPASSS SECSLIRMGF PQHTIASLSD QDAKPSFSMA HLDGNTEPGL TLGGYFCPQC RAKYCELPVE CKICG (ATA-APrEST89535)

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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