Anti-Growth Hormone (Human)

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Growth hormone (GH) is mapped to 17q22-q24. GH is synthesized by acidophilic or somatotropic cells of the anterior pituitary gland. Human Growth hormone has a molecular mass of 22,005 and contains 191 amino acid residues with 2 disulfide bridges. It binds two receptor molecules and thereby induces signal transduction through receptor dimerization. At high concentrations, GH acts as an antagonist because of a large difference in affinities at the respective binding sites. Protein function: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. [The UniProt Consortium]