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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
G8170-40X.100 | 100 µl | - | - |
3 - 19 business days* |
780.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Glycogen Synthase Kinase 3 differs from most serine/threonine kinases in that it is active in the... more
Product information "Anti-Glycogen Synthase Kinase 3 alpha, beta (GSK3a/b)"
Glycogen Synthase Kinase 3 differs from most serine/threonine kinases in that it is active in the absence of the action of signaling pathways. Two isoforms exist, GSK3 alpha and GSK3 beta. The function of GSK3 is to phosphorylate Glycogen Synthase and thereby inactivate it. Insulin action stimulates the PI3 Kinase pathway, resulting in Akt activation, which phosphorylates and inactivates GSK3. Glycogen Synthase is then rapidly dephosphorylated and activated. Other GSK3 substrates include Jun (on inhibitory sites), and eIF2B. Phosphorylation of Tau by GSK3 may relate to development of Alzheimer's disease. Phosphorylation state-specific antibodies directed against the Akt site (Ser21) on GSK3 are suitable for surrogate assays of the activation state of the pathway. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:1000, Immunoprecipitation: 2-8ul, Optimal dilutions to be determined by the researcher. Positive Control: HEK293 cell lysate. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-GSK3B, EC=2.7.11.1, EC=2.7.11.26, Anti-GSK-3 beta, Anti-Glycogen synthase kinase-3 beta, Anti-Serine/threonine-protein kinase GSK3B |
Supplier: | United States Biological |
Supplier-Nr: | G8170-40X |
Properties
Application: | IP, WB |
Antibody Type: | Monoclonal |
Clone: | 10F641 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | Syntheric peptide corresponding to N-terminal 6His-tagged recombinant full length human GSK3-Beta. |
Format: | Supernatant |
Database Information
KEGG ID : | K03083 | Matching products |
UniProt ID : | P49841 | Matching products |
Gene ID | GeneID 2932 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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