Anti-GDF15(ponsegromab biosimilar) mAb

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
DIM-BME100090.50	50 µg		-	-	7 - 16 business days*		115.00€
DIM-BME100090.100	100 µg		-	-	7 - 16 business days*		227.00€

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Protein function: Regulates food intake, energy expenditure and body weight in response to... more

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Product information "Anti-GDF15(ponsegromab biosimilar) mAb"

Protein function: Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435). Binds to its receptor, GFRAL, and activates GFRAL- expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28953886). On hepatocytes, inhibits growth hormone signaling. [The UniProt Consortium]

Keywords:	Anti-GDF-15, Anti-MIC-1, Anti-MIC1, Anti-NAG-1, Anti-PDF, Anti-PLAB, Anti-PTGFB, Anti-GDF15(ponsegromab biosimilar) mAb
Supplier:	DIMA
Supplier-Nr:	BME100090

Properties

Antibody Type:	Monoclonal
Conjugate:	No
Host:	Humanized
Species reactivity:	human
Format:	Lyophilized

Database Information

CAS :	12\| Matching products
UniProt ID :	Q99988 \| Matching products

Handling & Safety

Storage:	-20°C (avoid repeat freezing and thawing cycles)
Shipping:	+20°C (International: +20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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