Anti-GABAA Receptor alpha 1

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Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Discount	Price
ARG40697.50	50 µg		-	-	6 - 14 business days*		30 %	520.00€ 364.00€

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Protein function: Ligand-gated chloride channel which is a component of the heteropentameric... more

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Product information "Anti-GABAA Receptor alpha 1"

Protein function: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:23909897, PubMed:25489750, PubMed:29950725). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:23909897, PubMed:25489750). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (PubMed:23909897, PubMed:25489750). GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection. Functions also as histamine receptor and mediates cellular responses to histamine. [The UniProt Consortium]

Keywords:	Anti-GABRA1, Anti-GABA(A) receptor subunit alpha-1, Anti-Gamma-aminobutyric acid receptor subunit alpha-1
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG40697

Properties

Application:	IHC (paraffin), WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	rat (Expected: hamster)
Immunogen:	Synthetic peptide corresponding to aa. 440-456 of Human GABAA Receptor alpha 1. (ATYLNREPQLKAPTPHQ)
MW:	52 kD
Format:	Antigen Affinity Purified