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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-30-1498-0.1 | 100 µg | - |
3 - 11 business days* |
580.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
FOLR2 (folate receptor beta) is a cell surface protein that was originally thought to be specific... more
Product information "Anti-FOLR2 Monoclonal Antibody (Clone:EM-35)"
FOLR2 (folate receptor beta) is a cell surface protein that was originally thought to be specific for placenta, but it can be also expressed in other tissues, including hematopoietic cells. Its expression is increased in malignant tissues. FOLR2 may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. FOLR2 is a marker for macrophages generated in the presence of M-CSF (M2), including M2-like tumor-associated macrophages, which exert potent immunosuppressive functions within the tumor environment, but not GM-CSF (M1), and whose expression correlates with increased folate uptake ability. Protein function: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. [The UniProt Consortium]
Keywords: | Anti-FBP, Anti-FOLR2, Anti-FR-beta, Anti-Folate receptor 2, Anti-Folate receptor beta, Anti-Folate receptor, fetal/placental, Anti-Placental folate-binding protein, Anti-FOLR2 Monoclonal Antibody (Clone:EM-35) |
Supplier: | Abeomics |
Supplier-Nr: | 30-1498 |
Properties
Application: | FC, IP, WB, ICC |
Antibody Type: | Monoclonal |
Clone: | EM-35 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | BW5147alpha,beta- cells |
Format: | Affinity Purified |
Database Information
KEGG ID : | K13649 | Matching products |
UniProt ID : | P14207 | Matching products |
Gene ID | GeneID 2350 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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You will get a certificate here
-30 %
Discount Promotion
-30 %
Discount Promotion
-30 %
Discount Promotion
-30 %
Discount Promotion
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