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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
G-PACO58997.50 | 50 µg | - |
9 - 20 business days* |
363.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
FAN1 Antibody is a IgG polyclonal antibody from Assay Genie with reactivity against Human and for... more
Product information "Anti-FAN1"
FAN1 Antibody is a IgG polyclonal antibody from Assay Genie with reactivity against Human and for use in ELISA, WB, IHC applications. FAN1 Antibody is a high quality polyclonal antibody for research use only.. Protein function: Nuclease required for the repair of DNA interstrand cross- links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866). [The UniProt Consortium]
Keywords: | Anti-hFAN1, Anti-Fanconi-associated nuclease 1, Anti-Myotubularin-related protein 15, Anti-FANCD2/FANCI-associated nuclease 1 |
Supplier: | Assay Genie |
Supplier-Nr: | PACO58997 |
Properties
Application: | ELISA, WB, IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Recombinant Human Fanconi-associated nuclease 1 protein (167-373AA) |
Database Information
KEGG ID : | K15363 | Matching products |
UniProt ID : | Q9Y2M0 | Matching products |
Gene ID | GeneID 22909 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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