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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-R30294 | 100 µg | - | - |
3 - 10 business days* |
755.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Estrogen receptor-beta, referred to as... more
Product information "Anti-Estrogen Receptor (beta)"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Estrogen receptor-beta, referred to as ESR2 or ERb, is a member of the superfamily of nuclear receptors which can transduce extracellular signals into transcriptional responses. This gene is mapped to 14q and comprises 8 exons spanning approximately 40 kb. It is expressed in multiple tissues, including developing spermatids of the testis and in ovarian granulosa cells. ERb is homologous to the previously identified ERa and has an overlapping but nonidentical tissue distribution. The DNA-binding domain of ERb is 96% conserved compared to ERa, and the ligand-binding domain shows 58% conserved residues. Estrogen receptor beta is expressed in human thymus, spleen, ovary, and testis. ERb mRNA was coexpressed with ERa and its splice variants in 60% of prolactinomas, 100% of mixed growth hormone /prolactin tumors, and 29% of gonadotroph tumors. Gene expression was not limited to ERa-positive tumor subtypes, however, and was also found in 100% of null cell tumors, 80% of somatotroph tumors, and 60% of corticotroph tumors. Protein function: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen- dependent manner (PubMed:20074560). [The UniProt Consortium]
Keywords: | Anti-ESR2, Anti-ESTRB, Anti-ER-beta, Anti-Estrogen receptor beta, Anti-Nuclear receptor subfamily 3 group A member 2, Estrogen Receptor Antibody (beta) |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | R30294 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | An amino acid sequence from the N-terminus of human Estrogen Receptor beta (HGSIYIPSSYVDSHHEYPAMTFYS) |
Format: | Purified |
Database Information
KEGG ID : | K08551 | Matching products |
UniProt ID : | Q92731 | Matching products |
Gene ID | GeneID 2100 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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