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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-10-7546-25 | 25 µg | - |
3 - 11 business days* |
149.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Epithelial cadherin (E-cadherin) is a calcium dependent cell-cell adhesion glycoprotein. It is... more
Product information "Anti-E-cadherin (Clone: ABM43F8)"
Epithelial cadherin (E-cadherin) is a calcium dependent cell-cell adhesion glycoprotein. It is associated with gland formation, stratification, and epithelial polarization. Its deregulation affects cell-cell adhesion and results in increased invasiveness of distinct human carcinomas like gastric cancer, malignancy, oral squamous cell carcinoma, Atypical parathyroid adenoma (APA). Loss of function of E-cadherin leads to the disappearance of epithelial characteristics of the cells and generates higher invasiveness for extracellular matrices. E-cadherin expression is considered to be a decisive indicator for differentiation, aggressive behaviour, high proliferation, metastasis, poor prognosis and invasiveness of human carcinoma cells. Protein function: Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. [The UniProt Consortium]
Keywords: | Anti-CDHE, Anti-CDH1, Monoclonal Antibody to E-cadherin (Clone: ABM43F8) |
Supplier: | Abeomics |
Supplier-Nr: | 10-7546-25 |
Properties
Application: | IHC, WB |
Antibody Type: | Monoclonal |
Clone: | ABM43F8 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | A partial length recombinant E-cadherin protein (amino acids 438-556) was used as the immunogen for this antibody . |
Format: | Purified |
Database Information
KEGG ID : | K05689 | Matching products |
UniProt ID : | P12830 | Matching products |
Gene ID | GeneID 999 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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