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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ATA-HPA034657.25 | 25 µl | - |
7 - 10 business days* |
335.00€
|
|||
ATA-HPA034657.100 | 100 µl | - |
7 - 10 business days* |
446.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Component of the cleavage and polyadenylation specificity factor (CPSF) complex... more
Product information "Anti-CPSF3"
Protein function: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'- end-processing endonuclease. Also involved in the histone 3'-end pre- mRNA processing. U7 snRNP-dependent protein that induces both the 3'- endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7- dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner. Required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation via its interaction with ISY1. Required for the biogenesis of all miRNAs from the pri- miR-17-92 primary transcript except miR-92a. Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290- 295 and pri-miR-96-183 primary transcripts, respectively. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 95% and to rat: 95%
Keywords: | Anti-CPSF3, Anti-CPSF73, Anti-CPSF 73 kDa subunit, Anti-mRNA 3'-end-processing endonuclease CPSF-73, Anti-Cleavage and polyadenylation specificity factor subunit 3, Anti-Cleavage and polyadenylation specificity factor 73 kDa subunit |
Supplier: | Atlas Antibodies |
Supplier-Nr: | HPA034657 |
Properties
Application: | IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: PFNLLCYQLQ KLTGDVEELE IQEKPALKVF KNITVIQEPG MVVLEWLANP SNDMYADTVT TVILEVQSNP KIRKGAVQK (ATA-APrEST79018) |
Database Information
KEGG ID : | K14403 | Matching products |
UniProt ID : | Q9UKF6 | Matching products |
Gene ID | GeneID 51692 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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