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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-F53608-0.1ML | 100 µl | - | - |
3 - 10 business days* |
702.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
In ascites with 0.09% sodium azide. This gene is overexpressed in breast cancer and squamous cell... more
Product information "Anti-Cortactin, clone 401CT8.6.3"
In ascites with 0.09% sodium azide. This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. Protein function: Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones. Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density. Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). Plays a role in focal adhesion assembly and turnover. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits. Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). [The UniProt Consortium]
Keywords: | Anti-CTTN, Anti-EMS1, Anti-Amplaxin, Anti-Oncogene EMS1, Anti-Src substrate cortactin, Cortactin Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | F53608 |
Properties
Application: | WB, ELISA |
Antibody Type: | Monoclonal |
Clone: | 401CT8.6.3 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Purified His-tagged Cortactin protein fragment was used to produced this monoclonal Cortactin antibody. |
Format: | Purified |
Database Information
KEGG ID : | K06106 | Matching products |
UniProt ID : | Q14247 | Matching products |
Gene ID | GeneID 2017 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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