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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-30-1220-0.1 | 100 µg | - |
3 - 11 business days* |
594.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein... more
Product information "Anti-CD46 / Membrane Cofactor Protein Monoclonal Antibody (Clone:MEM-258)"
CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa. Protein function: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement- mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T- cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. [The UniProt Consortium]
Keywords: | Anti-MCP, Anti-TLX, Anti-CD46, Anti-Membrane cofactor protein, Anti-Trophoblast leukocyte common antigen, Anti-CD46 / Membrane Cofactor Protein Monoclonal Antibody (Clone:MEM-258) |
Supplier: | Abeomics |
Supplier-Nr: | 30-1220 |
Properties
Application: | FC, IP, WB |
Antibody Type: | Monoclonal |
Clone: | MEM-258 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human, bovine |
Immunogen: | HPB-ALL human T cell line |
Format: | Affinity Purified |
Database Information
KEGG ID : | K04007 | Matching products |
UniProt ID : | P15529 | Matching products |
Gene ID | GeneID 4179 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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You will get a certificate here
-30 %
Discount Promotion
-30 %
Discount Promotion
-30 %
Discount Promotion
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