Anti-CD3z (mouse) (CD247) (PE), clone H146-968

Anti-CD3z (mouse) (CD247) (PE), clone H146-968
Item number Size Datasheet Manual SDS Delivery time Quantity Price
G-AGIM0540.100 100 µl -

9 - 20 business days*

213.00€
 
Protein function: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an... more
Product information "Anti-CD3z (mouse) (CD247) (PE), clone H146-968"
Protein function: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity- dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN). [The UniProt Consortium]
Keywords: Anti-Cd3z, Anti-CD247, Anti-Cd247, Anti-T-cell receptor T3 zeta chain, Anti-T-cell surface glycoprotein CD3 zeta chain, Mouse CD3z (CD247) monoclonal antibody (PE) (AGIM0540)
Supplier: Assay Genie
Supplier-Nr: AGIM0540

Properties

Application: FC
Antibody Type: Monoclonal
Clone: H146-968
Conjugate: Phycoerythrin
Host: Hamster
Species reactivity: mouse

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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