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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-R30595 | 100 µg | - | - |
3 - 10 business days* |
755.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Calcium/calmodulin-dependent protein... more
Product information "Anti-CaMKK"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Calcium/calmodulin-dependent protein kinase kinase 1 is an enzyme that in humans is encoded by the CAMKK1 gene. The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent(CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. CaMKK binds calmodulin and activated Camk4 with a 6-fold increase in total activity and a 100-fold increase in Camk4 Ca(2+)-independent activity. It catalyzed a 10-fold increase in the total activity of CaMK1 and had no effect on CaMK2. Cotransfection of COS-7 cells with CaMKK and Camk4 resulted in a 14-fold increase in CRE-binding protein-dependent transcription compared with Camk4 alone, suggesting that CaMKK enhances Camk4-mediated transcriptional regulation. Protein function: Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. [The UniProt Consortium]
Keywords: | Anti-Camkk, Anti-Camkk1, Anti-CaMKK 1, Anti-CaM-KK 1, Anti-CaMKK alpha, Anti-CaM-KK alpha, EC=2.7.11.17, Anti-CaM-kinase kinase 1, Anti-CaM-kinase IV kinase, Anti-CaM-kinase kinase alpha, Anti-Calcium/calmodulin-dependent protein kinase kinase 1, CaMKK An |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | R30595 |
Properties
Application: | WB, IHC (paraffin) |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Amino acids 10-31 (QDPRAELVDRVAAINVAHLEEA-mouse) were used as the immunogen for this CaMKK antibody. |
Format: | Purified |
Database Information
KEGG ID : | K00908 | Matching products |
UniProt ID : | Q8VBY2 | Matching products |
Gene ID | GeneID 55984 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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