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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
C0108-34E.1 | 1 ml | - | - |
3 - 19 business days* |
978.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Cadherins are transmembrane glycoproteins involved in Ca++-dependent cell adhesion. The cadherin... more
Product information "Anti-Cadherin E (Cadherin-1, E-Cadherin, L-CAM, Epithelial Cell Adhesion Molecule, Uvomorulin, CDH1)"
Cadherins are transmembrane glycoproteins involved in Ca++-dependent cell adhesion. The cadherin family, including E-Cadherin, N-Cadherin, P-Cadherin and R-Cadherin, plays an important role in tissue morphogenesis and structure. E- cadherin is a 120kD protein that mediates Ca++-dependent adhesion between epithelial cells and is involved in the generation of epithelial layers during development and the and maintenance of epithelial tissue in adults. The presence of E-cadherin has been reported in other cell types, including osteoblasts, peripheral nerve Schwann cells and Langerhans cells. The large number of papers linking E-cadherin, or lack of E-cadherin expression, with a broad range of cancers suggests that its immunodetection in tissue may be useful in the diagnosis and prognosis of a variety of cancers. Tumor analysis by immunohistochemical techniques revealed that the reduction and/or loss of E-cadherin expression in carcinomas (including tumors of the neck, prostate, esophagus and other cancers) correlates positively with tumor cell invasion and metastasis. Studies have also associated reduced expression of E-cadherin with invasiveness and poor prognosis in breast cancer and poor prognosis in bladder cancer. Other studies have indicated that analysis of E-cadherin and N-cadherin expression may be useful in differentiating pleural mesotheliomas (N-cadherin positive) and lung adenocarcinomas (E-cadherin positive). Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilutions: Immunohistochemistry (Formalin-fixed, paraffin-embedded or frozen sections): 1:50-1:200. Epitope retrieval required (Citrate Buffer, pH 6)., Optimal dilutions to be determined by the researcher., ., Recommended Positive Control: , Non-neural epithelia tissue , Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Supplier: | United States Biological |
Supplier-Nr: | C0108-34E |
Properties
Application: | IHC |
Antibody Type: | Monoclonal |
Clone: | 3G47 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Format: | Purified |
Database Information
KEGG ID : | K05689 | Matching products |
UniProt ID : | P12830 | Matching products |
Gene ID | GeneID 999 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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