Zu "K25015" wurden 24 Artikel gefunden!
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Ensitrelvir fumarate
Artikelnummer: TGM-T40358-2mg
Description: Ensitrelvir (S-217622) fumarate is a novel orally active inhibitor targeting the SARS-CoV-2 3CL protease (IC50 = 13 nM), demonstrating non-covalent and non-peptidic characteristics. This compound represents a pioneering advancement in the development of effective antiviral agents against the SARS-CoV-2...
| Schlagworte: | S-217622 fumarate |
| Anwendung: | Targets SARS coronavirus 3C-like proteinase [EC:3.4.22.69] (nsp5) |
| CAS | 2757470-18-9 |
| MW: | 647.96 D |
54,00 €
Pomotrelvir
Artikelnummer: TGM-T73052-100mg
Description: Pomotrelvir (PBI-0451) is a selective, orally administered inhibitor of the SARS-CoV-2 3CL protease with antiviral properties, making it suitable for novel coronavirus (COVID-19) research. Target: Others. Smiles: ClC1=C2C(C=C(C(N[C@@H](CC3CC3)C(N[C@@H](C[C@H]4C(=O)NCCC4)C#N)=O)=O)N2)=CC=C1
| Schlagworte: | PBI-0451 |
| Anwendung: | Targets SARS coronavirus 3C-like proteinase [EC:3.4.22.69] (nsp5) |
| CAS | 2713437-86-4 |
| MW: | 455.94 D |
ab 1.671,00 €
ML188
Artikelnummer: TGM-T8371-100mg
Description: ML188 is a selective noncovalent SARS-CoV 3CLpro inhibitor(IC50 : 1.5 µM), with moderate MW and good enzyme and antiviral inhibitory activity. Target: SARS-CoV, Virus Protease. Smiles: CC(C)(C)NC(=O)[C@H](N(C(=O)c1ccco1)c1ccc(cc1)C(C)(C)C)c1cccnc1. References: Jacobs J , Grum-Tokars V , Zhou Y , et al....
| Anwendung: | SARS-CoV Mpro inhibitor |
| CAS | 1417700-13-0 |
| MW: | 433.54 D |
ab 49,00 €
(Rac)-X77
Artikelnummer: TGM-T8688-100mg
Description: (Rac)-X77 (MUN91789) is a potent SARS- CoV- 2 main protease inhibitor. Target: SARS-CoV. Smiles: CC(C)(C)c1ccc(cc1)N(C(C(=O)NC1CCCCC1)c1cccnc1)C(=O)c1cnc[nH]1. References: Andrianov A M , Kornoushenko Y V , Karpenko A D , et al. Computational Discovery of Small Drug-like Compounds as Potential...
| Schlagworte: | CPD77, MUN91789 |
| Anwendung: | SARS-CoV-2 Mpro inhibitor |
| CAS | 2144491-78-9 |
| MW: | 459.58 D |
ab 74,00 €
Nirmatrelvir
Artikelnummer: TGM-T9351-100mg
Description: PF-07321332 is a potent and orally active inhibitor of SARS-CoV 3C-like protease (3CLPRO) . Target: SARS-CoV. Smiles: C(N[C@@H](C[C@H]1C(=O)NCC1)C#N)(=O)[C@@H]2[C@@]3([C@@](C3(C)C)(CN2C([C@@H](NC(C(F)(F)F)=O)[C@](C)(C)C)=O)[H])[H]. References: Li J, et al. Nirmatrelvir exerts distinct antiviral potency...
| Anwendung: | Targets SARS coronavirus 3C-like proteinase [EC:3.4.22.69] (nsp5) |
| CAS | 2628280-40-8 |
| MW: | 499.53 D |
ab 54,00 €
PF-00835231
Artikelnummer: TGM-T9458-100mg
Description: PF-00835231 is a CoV-2 cysteine 3C-like protease (3CLpro) inhibitor, with IC50s of 0.27 nM and 4 nM for SARS CoV-2 and SARS CoV-1 3CLpro, respectively. PF-00835231 is the active compound of the first anti-3CLpro regimen in clinical trials. Target: SARS-CoV. Smiles:...
| Anwendung: | SARS-CoV / SARS-CoV-2 Mpro inhibitor |
| CAS | 870153-29-0 |
| MW: | 472.53 D |
ab 52,00 €
Ensitrelvir
Artikelnummer: TGM-T9716-10mg
Description: Ensitrelvir (S-217622) is an orally active inhibitor of SARS-CoV-2 3CL protease with IC50 of 13 nM. Target: SARS-CoV. Smiles: Cn1nc(cc(c(/N=C(\NC(N2Cc3nn(C)cn3)=O)/N(Cc(cc(c(F)c3)F)c3F)C2=O)c2)Cl)c2c1. References: Yuto Unoh, et al. Discovery of S-217622, a Non-Covalent Oral SARS-CoV-2 3CL Protease...
| Schlagworte: | S-217622 |
| Anwendung: | Targets SARS coronavirus 3C-like proteinase [EC:3.4.22.69] (nsp5) |
| CAS | 2647530-73-0 |
| MW: | 531.88 D |
ab 49,00 €
Cinanserin hydrochloride
Artikelnummer: TGM-T14968-100mg
Description: Cinanserin hydrochloride (SQ 10643), a high-affinity antagonist of the 5-HT2 receptor (Ki: 41 nM), is also a 3C-like protease inhibitor of severe acute respiratory syndrome coronavirus. Target: 5-HT Receptor, Influenza Virus. Smiles: Cl.CN(C)CCCSc1ccccc1NC(=O)C=Cc1ccccc1. References: Chen L, et al....
| Schlagworte: | SQ 10643 |
| Anwendung: | Targets SARS coronavirus 3C-like proteinase [EC:3.4.22.69] (nsp5) |
| CAS | 54-84-2 |
| MW: | 376.94 D |
ab 31,00 €
rac-X77
Artikelnummer: Cay40779-10
rac-X77 is an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), also known as 3C-like protease (3CLpro, IC50 = 4.1 µM).Formal Name: N-cyclohexyl-alpha-[[4-(1,1-dimethylethyl)phenyl](1H-imidazol-5-ylcarbonyl)amino]-3-pyridineacetamide. CAS Number: 2144491-78-9. Molecular...
| Schlagworte: | N-cyclohexyl-alpha-[[4-(1,1-dimethylethyl)phenyl](1H-imidazol-5-ylcarbonyl)amino]-3-pyridineacetamide |
| Anwendung: | SARS-CoV-2 Mpro inhibitor |
| CAS | 2144491-78-9 |
| MW: | 459.6 D |
ab 376,00 €
COVID-19 Forschung
PF-07321332
Artikelnummer: Cay35257-1
PF-07321332 is an orally bioavailable inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), also known as 3C-like protease (3CLpro), with a Ki value of 3.11 nM. It also inhibits Mpro from other members of the Betacoronavirus genus, including SARS-CoV-1, HKU1-CoV, OC43-CoV,...
| Schlagworte: | Nirmatrelvir,... |
| Anwendung: | SARS-CoV-2 Mpro inhibitor |
| CAS | 2628280-40-8 |
| MW: | 499.5 D |
ab 122,00 €
Ensitrelvir
Artikelnummer: Cay37945-5
Ensitrelvir is an orally bioavailable inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), also known as 3C-like protease (3CLpro), with an IC50 value of 0.013 µM. It is selective for Mpro over HIV-1 protease and the human proteases caspase-2, chymotrypsin, thrombin, and...
| Schlagworte: | S-217622,... |
| Anwendung: | SARS-CoV-2 Mpro inhibitor |
| CAS | 2647530-73-0 |
| MW: | 531.9 D |
ab 49,00 €
PF-00835231
Artikelnummer: Cay36047-1
PF-00835231 is an inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 main protease (Mpro), also known as 3C-like protease (3CLpro, Kis = 4 and 0.27 nM, respectively). It reduces the infectivity of SARS-CoV and common cold human coronavirus 229E (HCoV-229E) in Vero cells (EC50s = 4.8...
| Schlagworte: | N-[(1S)-1-[[[(1S)-3-hydroxy-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]propyl]amino]carbonyl]-3-methylbutyl]-4-methoxy-1H-... |
| Anwendung: | SARS-CoV / SARS-CoV-2 Mpro inhibitor |
| CAS | 870153-29-0 |
| MW: | 472.5 D |
ab 77,00 €