Zu "K24803" wurden 15 Artikel gefunden!
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Dolutegravir
Artikelnummer: TGM-T6198-100mg
Description: Dolutegravir (GSK1349572) (IC50=2.7 nM), a two-metal-binding HIV integrase inhibitor, exhibits medium activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. Target: HIV Protease. Smiles: C[C@@H]1CCO[C@H]2Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c(O)c3C(=O)N12. References:...
| Schlagworte: | S/GSK1349572, GSK1349572 |
| Anwendung: | Targets HIV-1 integrase (IN) |
| CAS | 1051375-16-6 |
| MW: | 419.38 D |
ab 31,00 €
HIV-1 integrase inhibitor 9
Artikelnummer: TGM-T62156-100mg
Description: HIV-1 integrase inhibitor 9 (compound 8a) is a potent inhibitor of HIV-1 RNase H (IC50: 12.3 µM) with antiviral effects. Target: Others. Smiles: OC1=C2C(C=C(C(NC3=CC(C(OC)=O)=C(O)C=C3)=O)C(=O)O2)=CC(N(=O)=O)=C1O
| Anwendung: | HIV-1 integrase inhibitor |
| CAS | 2709085-95-8 |
| MW: | 416.3 D |
ab 1.520,00 €
Cabotegravir sodium
Artikelnummer: TGM-T62328-5mg
Description: Cabotegravir sodium is a potent inhibitor of HIV integrase and is able to act on HIVADA (IC50: 2.5 nM). cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1 and is less likely to interact with other antiretroviral drugs (ARVs). Antileishmanial agent-12....
| Anwendung: | Targets HIV-1 integrase (IN) |
| CAS | 1051375-13-3 |
| MW: | 427.34 D |
31,00 €
BMS-707035
Artikelnummer: TGM-T6420-100mg
Description: BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2. Target: HIV Protease. Smiles: Cn1c(nc(C(=O)NCc2ccc(F)cc2)c(O)c1=O)N1CCCCS1(=O)=O. References: Dicker IB, et al. J Biol Chem, 2007, 282(43), 31186-31196.
| Anwendung: | HIV-1 integrase DNA strand transfer inhibitor |
| CAS | 729607-74-3 |
| MW: | 410.42 D |
ab 34,00 €
Cabotegravir
Artikelnummer: TGM-T6098-100mg
Description: Cabotegravir (S/GSK1265744) (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (IC50: 3.0 nM). Target: HIV Protease. Smiles: O=C1C=2N(C[C@@]3(N1[C@@H](C)CO3)[H])C=C(C(NCC4=C(F)C=C(F)C=C4)=O)C(=O)C2O. References: Yoshinaga T,...
| Schlagworte: | GSK-1265744, GSK744, S/GSK1265744 |
| Anwendung: | Targets HIV-1 integrase (IN) |
| CAS | 1051375-10-0 |
| MW: | 405.35 D |
ab 46,00 €
HIV-1 integrase inhibitor 7
Artikelnummer: TGM-T11565-100mg
Description: HIV-1 integrase inhibitor 7 is a potent inhibitor of HIV-1 integrase (IC50: 33.3 nM). Target: Others. Smiles: O(C(C)=O)C1=C(OC(C)=O)C=CC(C=CC(O[C@H]([C@@H](OC(C=CC2=CC(OC(C)=O)=C(OC(C)=O)C=C2)=O)C(O)=O)C(O)=O)=O)=C1. References: Saíz-Urra L, et al. Quantitative structure-activity relationship studies of...
| Anwendung: | HIV-1 integrase inhibitor |
| CAS | 204268-03-1 |
| MW: | 642.52 D |
ab 1.520,00 €
HIV-1 integrase inhibitor 3
Artikelnummer: TGM-T11567-100mg
Description: HIV-1 integrase inhibitor 3 is an HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 2.7 nM. Target: Others. Smiles: NC=1C=2C(N(O)C(=O)C1C(NCC3=C(F)C=C(F)C=C3)=O)=NC=C(CCCCCO)C2. References: Zhao XZ, et al. HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug...
| Anwendung: | HIV-1 integrase inhibitor |
| CAS | 1638504-56-9 |
| MW: | 432.42 D |
ab 1.971,00 €
HIV-1 integrase inhibitor 4
Artikelnummer: TGM-T11568-100mg
Description: HIV-1 integrase inhibitor 4 is an HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 3.7 nM. Target: Others. Smiles: NC=1C=2C(N(O)C(=O)C1C(NCC3=C(F)C=C(F)C=C3)=O)=NC=C(CCS(=O)(=O)C4=CC=CC=C4)C2. References: Zhao XZ, et al. HIV-1 Integrase Strand Transfer Inhibitors with Reduced...
| Anwendung: | HIV-1 integrase inhibitor |
| CAS | 1638504-66-1 |
| MW: | 514.5 D |
ab 1.671,00 €
Bictegravir
Artikelnummer: TGM-T4493-100mg
Description: Bictegravir (GS-9883) is a potent inhibitor of HIV-1 integrase with an IC50 value of 7.5 nM. Target: HIV Protease. Smiles: O=C1N2C(CN3C1=C(O)C(=O)C(C(NCC4=C(F)C=C(F)C=C4F)=O)=C3)(O[C@]5(C[C@@]2(CC5)[H])[H])[H]. References: Tsiang M, et al. Antiviral Activity of Bictegravir (GS-9883), a Novel Potent...
| Schlagworte: | GS-9883 |
| Anwendung: | Targets HIV-1 integrase (IN) |
| CAS | 1611493-60-7 |
| MW: | 449.38 D |
ab 43,00 €
HIV-1 Integrase Inhibitor
Artikelnummer: Cay38779-10
HIV-1 integrase inhibitor is an inhibitor of HIV-1 integrase strand transfer (IC50s = 0.07 and 0.33 µM in the presence of manganese and magnesium, respectively). It is selective for HIV-1 integrase strand transfer over HIV-1 integrase 3' DNA processing (IC50 = >70 µM in the presence of either manganese or magnesium)...
| Schlagworte: | 118-D-24, MA-DKA, 4-[3-(azidomethyl)phenyl]-2-hydroxy-4-oxo-2-butenoic acid |
| Anwendung: | HIV-1 integrase strand transfer inhibitor |
| CAS | 544467-07-4 |
| MW: | 247.2 D |
ab 40,00 €
HIV-1 Integrase Inhibitor 1
Artikelnummer: Cay36807-10
HIV-1 integrase inhibitor 1 is an inhibitor of HIV-1 integrase DNA strand transfer (IC50 = 14 nM). It is also an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), also known as 3C-like protease (3CLpro), when used at a concentration of 10 µM in a fluorescence-based...
| Schlagworte: | BMS-707035,... |
| Anwendung: | HIV-1 integrase DNA strand transfer inhibitor |
| CAS | 729607-74-3 |
| MW: | 410.4 D |
ab 175,00 €
Bictegravir (sodium salt)
Artikelnummer: Cay37488-10
Bictegravir is an inhibitor of HIV-1 integrase (IC50 = 7.5 nM for strand transfer activity). It has antiviral activity against clinical isolates of HIV-1 in human peripheral blood mononuclear cells (PBMCs, EC50s = 0.04-1.7 nM). Bictegravir also inhibits HIV-1 viral infection in MT-2 and MT-4 cells, CD4+ T cells, and...
| Schlagworte: | GS-9883,... |
| Anwendung: | HIV-1 integrase inhibitor |
| CAS | 1807988-02-8 |
| MW: | 471.4 D |
ab 98,00 €