Zu "K22745" wurden 31 Artikel gefunden!
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viFSP1
Artikelnummer: Cay39927-1
viFSP1 is a species-independent inhibitor of ferroptosis suppressor protein 1 (FSP1, IC50s = 34 and 83 nM for the human and mouse enzymes, respectively). It induces ferroptosis in glutathione peroxidase 4 (Gpx4) knockout Pfa1 mouse embryonic fibroblasts expressing human or mouse FSP1, an effect that can be reversed...
| Schlagworte: | Versatile Inhibitor of Ferroptosis Suppressor Protein 1, Versatile Inhibitor of FSP1,... |
| Anwendung: | FSP1 (AIFM2) inhibitor |
| CAS | 951945-67-8 |
| MW: | 331.4 D |
ab 93,00 €
FSEN1
Artikelnummer: TGM-T77765-100mg
Description: FSEN1 is a novel and highly effective non-competitive FSP1 inhibitor with an IC50 value of 313 nM. FSEN1 induces ferroptosis in cancer cells by inhibiting FSP1. FSEN1 can be used to prevent and treat cancer. Target: Ferroptosis. Smiles: COC1=CC=C(C=C1)N1CCN(CC2=CN3C(S2)=NN=C3C2=CC=C(Br)C=C2)CC1....
| Schlagworte: | 3-(4-bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole |
| Anwendung: | FSP1 (AIFM2) inhibitor |
| CAS | 862808-01-3 |
| MW: | 484.41 D |
ab 44,00 €
Anti-AIFM2
Artikelnummer: CSB-PA000868.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-FSP1, Anti-AMID, Anti-p53-responsive gene 3 protein, Anti-Ferroptosis suppressor protein 1, Anti-Apoptosis-inducing... |
| Anwendung: | ELISA, WB, IHC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, monkey |
ab 106,00 €
iFSP1
Artikelnummer: Cay29483-10
iFSP1 is an inhibitor of apoptosis inducing factor mitochondria-associated 2/ferroptosis suppressor protein 1 (AIFM2/FSP1). It decreases cell viability in wild-type, but not glutathione peroxidase 4 (GPX4) knock-out, Pfa1 and HT1080 cells overexpressing AIFM2/FSP1, an effect that can be blocked by the ferroptosis...
| Schlagworte: | 1-amino-3-(4-methylphenyl)-pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile |
| Anwendung: | AIFM2 inhibitor |
| CAS | 150651-39-1 |
| MW: | 323.4 D |
ab 43,00 €
FSP1 Fluorescent Inhibitor Screening Assay Kit
Artikelnummer: Cay701900-96
Cayman's FSP1 Fluorescent Inhibitor Screening Assay Kit provides a robust and easy-to-use platform for identifying novel inhibitors of human FSP1, a negative regulator of the ferroptosis pathway. The assay measures the reduction of resazurin by FSP1 into resorufin, which can be easily quantified using a fluorescence...
| Schlagworte: | AMID, FSP1, p53-responsive gene 3 protein, Ferroptosis suppressor protein 1, Apoptosis-inducing factor homologous... |
| Anwendung: | Fluorometric/photometric inhibitor screening assay |
924,00 €
FSP1 (human, recombinant)
Artikelnummer: Cay29611-50
Ferroptosis suppressor protein 1 (FSP1), also known as apoptosis-inducing factor mitochondria-associated 2 (AIFM2), is a flavoprotein and NAD(P)H-dependent oxidoreductase that inhibits ferroptosis in a glutathione peroxidase 4- and glutathione-independent manner. It is encoded by AIFM2 in humans and is composed of a...
| Schlagworte: | AMID, FSP1, AMID, FSP1, AMID, p53-responsive gene 3 protein, p53-responsive gene 3 protein, Ferroptosis suppressor protein... |
693,00 €
FSEN1
Artikelnummer: Cay38025-5
FSEN1 is an inhibitor of ferroptosis suppressor protein 1 (FSP1, IC50 = 313 nM). It is selective for FSP1 over NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1, IC50 = >100 µM). FSEN1 induces cell death in GPX4-/- H460 non-small cell lung cancer (NSCLC) cells (EC50 = 69.36 nM) but not control H460 cells expressing...
| Schlagworte: | Ferroptosis Sensitizer 1, 3-(4-bromophenyl)-6-[[4-(4-methoxyphenyl)-1-piperazinyl]methyl]-thiazolo[2,3-c]-1,2,4-triazole |
| Anwendung: | FSP1 (AIFM2) inhibitor |
| CAS | 862808-01-3 |
| MW: | 484.4 D |
ab 39,00 €
icFSP1 (trifluoroacetate salt)
Artikelnummer: Cay39347-1
icFSP1 is an inhibitor of ferroptosis suppressor protein 1 (FSP1). It induces condensation and phase separation of FSP1 in cells when used at a concentration of 2.5 µM but does not inhibit FSP1 enzymatic activity in a cell-free assay (IC50 = > 30 µM). icFSP1 induces ferroptosis in HT-1080 fibrosarcoma cells in a...
| Schlagworte: | 3,4,5-trimethoxy-N-[4-(2-methyl-4-oxo-3(4H)-quinazolinyl)phenyl]-benzeneacetamide, trifluoroacetate salt |
| Anwendung: | FSP1 inhibitor |
| MW: | 573.5 D |
ab 90,00 €
Anti-AIFM2
Artikelnummer: E-AB-17820.20
This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. Protein function: Oxidoreductase, which...
| Schlagworte: | Anti-AMID, Anti-AIFM2, EC=1.-.-.-, Anti-Apoptosis-inducing factor 2, Anti-p53-responsive gene 3 protein,... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 71,00 €
Anti-FSP1
Artikelnummer: Cay31406-500
Ferroptosis suppressor protein 1 (FSP1), also known as apoptosis-inducing factor mitochondria-associated 2 (AIFM2), is a flavoprotein and NAD(P)H-dependent oxidoreductase that inhibits ferroptosis in a glutathione peroxidase 4 (GPX4) and glutathione-independent manner. It is encoded by AIFM2 in humans and is...
| Schlagworte: | Anti-AMID, Anti-FSP1, Anti-AMID, Anti-FSP1, Anti-AMID, Anti-p53-responsive gene 3 protein, Anti-p53-responsive gene 3... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
456,00 €
Anti-AIFM2
Artikelnummer: ATA-HPA042309.100
Protein function: A NAD(P)H-dependent oxidoreductase involved in cellular oxidative stress response. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical- trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Cooperates with...
| Schlagworte: | Anti-FSP1, Anti-AMID, Anti-p53-responsive gene 3 protein, Anti-Ferroptosis suppressor protein 1, Anti-Apoptosis-inducing... |
| Anwendung: | IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 335,00 €
Anti-AIFM2
Artikelnummer: ATA-HPA028961.100
Protein function: A NAD(P)H-dependent oxidoreductase involved in cellular oxidative stress response. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical- trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Cooperates with...
| Schlagworte: | Anti-FSP1, Anti-AMID, Anti-p53-responsive gene 3 protein, Anti-Ferroptosis suppressor protein 1, Anti-Apoptosis-inducing... |
| Anwendung: | ICC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 335,00 €