Zu "K19496" wurden 74 Artikel gefunden!
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T16Ainh-A01
Artikelnummer: TGM-T13059-100mg
Description: T16Ainh-A01 is a potent inhibitor of TMEM16A Chloride channel, inhibiting TMEM16A-mediated chloride currents (IC50 of 1 µM),and functions as a calcium-activated chloride channel (CaCC). Target: Chloride channel. Smiles: CCc1c(C)[nH]c(SCC(=O)Nc2nc(cs2)-c2ccc(OC)cc2)nc1=O. References: Fedigan S, et al....
| Anwendung: | TMEM16A inhibitor, CaCC blocker |
| CAS | 552309-42-9 |
| MW: | 416.52 D |
ab 67,00 €
Eact
Artikelnummer: TGM-T15192-100mg
Description: Eact is a selective and potent TMEM16A activator that directly activates the TRPV1 channels in sensory nociceptors, thereby producing itch, acute nociception, and thermal hypersensitivity (brackets). Target: Chloride channel. Smiles: COCCN(C(=O)c1cc(OC)c(OC)c(OC)c1)c1nc(cs1)-c1ccccc1. References: Liu S,...
| Anwendung: | ANO1 activator |
| CAS | 461000-66-8 |
| MW: | 428.5 D |
ab 34,00 €
Ani9
Artikelnummer: TGM-T26630-1mg
Description: Ani9 is a high selective blocker of Anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A) with an IC50 of 77 nM and can be used in studies about ANO1 and the treatment of ancer, hypertension, pain, diarrhea and asthma. Target: Chloride channel. Smiles: COc1ccccc1\C=N\NC(=O)COc1ccc(Cl)cc1C. References:...
| Schlagworte: | Apelin-12 acetate (229961-08-4 Free base), Apelin-12 acetate (229961-08-4 Free base), Ani 9, Ani-9 |
| Anwendung: | ANO1 inhibitor |
| CAS | 356102-14-2 |
| MW: | 332.78 D |
ab 35,00 €
MONNA
Artikelnummer: TGM-T8960-100mg
Description: MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 : 80 nM). It induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions. Target: Chloride channel. Smiles: COc1cc(Nc2ccc(cc2C(O)=O)[N+]([O-])=O)cc2ccccc12. References: TMEM16A is implicated in the regulation of...
| Anwendung: | TMEM16A blocker |
| CAS | 1572936-83-4 |
| MW: | 338.31 D |
ab 35,00 €
Anti-ANO1
Artikelnummer: CSB-PA110575.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: ANO1. Antigen Species: Human
| Schlagworte: | Anti-ANO1, Anti-Anoctamin-1, Anti-Transmembrane protein 16A, Anti-Oral cancer overexpressed protein 2,... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 167,00 €
Anoctamin-1 (ANO1), partial, human, recombinant
Artikelnummer: CSB-EP713621HU2.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 806-892aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: SFTSDFIPRL VYLYMYSKNG TMHGFVNHTL SSFNVSDFQN GTAPNDPLDL GYEVQICRYK DYREPPWSEN KYDISKDFWA VLAARLA. Purity: Greater than 90% as...
| Schlagworte: | ANO1, Anoctamin-1, Transmembrane protein 16A, Oral cancer overexpressed protein 2, Tumor-amplified and overexpressed... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 17.6 kD |
ab 364,00 €
T16A(inh)-A01
Artikelnummer: Cay18518-10
Transmembrane protein 16A (TMEM16A, also known as anoctamin-1) is a calcium-activated chloride channel (CaCC) with roles in transepithelial anion transport and smooth muscle contraction. T16A(inh)-A01 is an aminophenylthiazole that inhibits transient TMEM16A-mediated chloride currents with an IC50 value of ~1 µM....
| Schlagworte: | 2-[(5-ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]-acetamide |
| Anwendung: | TMEM16A inhibitor, CaCC blocker |
| CAS | 552309-42-9 |
| MW: | 416.5 D |
ab 44,00 €
MONNA
Artikelnummer: Cay21917-1
MONNA is a selective inhibitor of anoctamin-1 (ANO1, IC50 = 0.08 µM in Xenopus oocytes), a calcium-activated chloride channel (CaCC). It is selective for ANO1 over the chloride channels bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator up to 10 µM. MONNA (10 µM)...
| Schlagworte: | 2-[(4-methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid |
| Anwendung: | TMEM16A blocker |
| CAS | 1572936-83-4 |
| MW: | 338.3 D |
ab 44,00 €
Anti-DOG1 (TMEM16A)
Artikelnummer: NSJ-R31414
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Anoctamin-1 (ANO1), also known as oral cancer overexpressed 2 (ORAOV2), Tumor-amplified and overexpressed sequence 2 (TMEM16A), and Discovered on gastrointestinal stromal tumors protein 1 (DOG1) is a protein that in humans is encoded by the ANO1 gene. This gene...
| Schlagworte: | Anti-DOG1, Anti-ANO1, Anti-Anoctamin-1, Anti-Transmembrane protein 16A, Anti-Oral cancer overexpressed protein 2,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
772,00 €
Anti-TMEM16A DOG1, clone DG1/447
Artikelnummer: NSJ-V2315-100UG
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Expression of TMEM16A (DOG1) protein is elevated in the gastrointestinal stromal tumors (GISTÆs), c-kit signaling-driven mesenchymal tumors of the GI tract. TMEM16A is rarely expressed in other soft tissue tumors, which, due to appearance, may be...
| Schlagworte: | Anti-ANO1, Anti-DOG1, Anti-Anoctamin-1, Anti-Transmembrane protein 16A, Anti-Oral cancer overexpressed protein 2,... |
| Anwendung: | FC, IHC, IF |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 361,00 €
Anti-TMEM16A DOG1, clone DG1/447
Artikelnummer: NSJ-V2315SAF-100UG
1 mg/ml in sterile PBS, BSA free, sodium azide free. Expression of TMEM16A (DOG1) protein is elevated in the gastrointestinal stromal tumors (GISTÆs), c-kit signaling-driven mesenchymal tumors of the GI tract. TMEM16A is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to...
| Schlagworte: | Anti-ANO1, Anti-DOG1, Anti-Anoctamin-1, Anti-Transmembrane protein 16A, Anti-Oral cancer overexpressed protein 2,... |
| Anwendung: | FC, IHC, IF |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
781,00 €
Anti-DOG1, clone DOG1.1
Artikelnummer: ARG58023.50
Protein function: Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a...
| Schlagworte: | Anti-ANO1, Anti-DOG1, Anti-Anoctamin-1, Anti-Transmembrane protein 16A, Anti-Oral cancer overexpressed protein 2,... |
| Anwendung: | FC, ICC, IF, IHC (paraffin) |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
641,00 €