Zu "K18438" wurden 41 Artikel gefunden!
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Ligustrazine
Artikelnummer: TGM-T2722-100mg
Description: Ligustrazine (Tetramethylpyrazine), a natural compound isolated from Chinese herbal medicine Ligusticum wallichii (Chuan Xiong) shows anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities. Target: Antioxidant, Apoptosis. Smiles: CC1=NC(C)=C(C)N=C1C. References: Guan D, et al. J...
| Schlagworte: | Tetramethylpyrazine |
| Anwendung: | Dihydropyrazine found in Ligusticum walliichi. PDE10A2 inhibitor, adenosine 2A/2B antagonist |
| CAS | 1124-11-4 |
| MW: | 136.19 D |
ab 31,00 €
Ligustrazine hydrochloride
Artikelnummer: TGM-T2953-1mL
Description: Ligustrazine hydrochloride (Chuanxiongzine hydrochloride) is a chemical compound found in natto and in fermented cocoa beans with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities. Target: Others. Smiles: C.Cc1nc(C)c(C)nc1C. References: Gao HJ, et al. Neural Regen Res. 2015...
| Schlagworte: | Tetrapyrazine HCl, Chuanxiongzine hydrochloride, Tetramethylpyrazine HCl, Tetramethylpyrazine hydrochloride |
| Anwendung: | Dihydropyrazine found in Ligusticum walliichi. PDE10A2 inhibitor, adenosine 2A/2B antagonist |
| CAS | 76494-51-4 |
| MW: | 172.66 D |
30,00 €
SEP-0372814
Artikelnummer: TGM-T8454-100mg
Description: SEP-0372814 is a potent inhibitor of PDE10. Target: PDE. Smiles: Cc1c(nc2c3cccnc3ccn12)[C@@H]1C[C@H]1c1nc2c(C)ncc(C)n2n1
| Anwendung: | PDE10A inhibitor |
| CAS | 1516895-53-6 |
| MW: | 369.42 D |
ab 81,00 €
Balipodect
Artikelnummer: TGM-T1745-100mg
Description: Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM), Its selectivity is >15000-fold over other PDEs. Target: PDE. Smiles: COc1cn(nc(-c2ccnn2-c2ccccc2)c1=O)-c1ccc(cc1F)-n1cccn1. References: Kunitomo J, et al. J Med Chem. 2014, 57(22):9627-43.
| Schlagworte: | TAK 063, TAK-063, TAK063 |
| Anwendung: | Targets cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10 (PDE10) |
| CAS | 1238697-26-1 |
| MW: | 428.42 D |
ab 33,00 €
Mardepodect
Artikelnummer: TGM-T16499-100mg
Description: Mardepodect (PF-2545920) is a phosphodiesterase inhibitor selective for the PDE10A subtype with an IC50 of 0.37 nM and over 1000-fold selectivity over PDE. It is potentially useful for the treatment of schizophrenia. Phosphodiesterase 10A (PDE10A) is highly expressed in striatal medium spiny neurons of...
| Schlagworte: | PF-2545920 |
| Anwendung: | Targets cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10 (PDE10) |
| CAS | 898562-94-2 |
| MW: | 392.45 D |
ab 37,00 €
Anti-PDE10A
Artikelnummer: CSB-PA282556.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-PDE10A, EC=3.1.4.35, EC=3.1.4.17, Anti-cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 5''-cyclic... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, rat |
ab 126,00 €
PDE10A1, active human recombinant protein, N-terminal GST...
Artikelnummer: BPS-60099
Human PDE10A1 (GenBank Accession No. NM_001130690), a.a. 2-789(end) with N-terminal GST-tag, MW=116 kDa, expressed in Sf9 cells via a Baculovirus expression system. One unit is defined as the amount of enzyme that will convert 1 pmole of 3',5'-cAMP to 5'- AMP per min at 37°C. Assay condition: 10 mM Tris-HCl, pH 7.4,...
| Schlagworte: | PDE10A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | Baculovirus |
| Ursprungsart: | human |
| MW: | 116 kD |
685,00 €
PDE10A2 Assay Kit
Artikelnummer: BPS-60400
The PDE10A Assay Kit is designed for identification of PDE10A inhibitors using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE10A to the binding agent. PDE10A is a dual substrate PDE highly expressed in striatal medium spiny neurons. PDE10A...
| Schlagworte: | inhibitor screening, assay kit, PDE10A, |
| Anwendung: | PDE10A2 assays, inhibitor screening, FP |
640,00 €
PDE10A2, active human recombinant protein
Artikelnummer: BPS-60100
Active human PDE10A2 (GenBank Accession No. NM_006661), full length with N-terminal GST tag, MW= 116 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
| Schlagworte: | PDE10A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 116 kD |
685,00 €
Papaverine
Artikelnummer: Cay10011133-100
Papaverine (Cay-10011133) is an analytical reference standard categorized as a muscle relaxant. Papaverine has been found as an impurity in seized heroin. This product is intended for research and forensic applications.Formal Name: 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy isoquinoline. CAS Number: 58-74-2....
| Schlagworte: | NSC 136630, 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy isoquinoline |
| Anwendung: | Analytical reference standard, smooth muscle relaxant, phosphodiesterase inhibitor |
| CAS | 58-74-2 |
| MW: | 339.4 D |
ab 128,00 €
TAK-063
Artikelnummer: Cay22208-5
TAK-063 is a potent inhibitor of phosphodiesterase 10A (PDE10A, IC50 = 0.3 nM). It is >15,000-fold selective for PDE10A over other PDEs and exhibits 14276, Cay-ISO60194) with a minimum effective dose (MED) of 0.3 mg/kg, p.o., in wild-type mice but has no effect in PDE10A knockout mice at doses up to 1 mg/kg. TAK-063...
| Schlagworte: | 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-4(1H)-pyridazinone |
| Anwendung: | PDE10A inhibitor |
| CAS | 1238697-26-1 |
| MW: | 428.4 D |
ab 117,00 €
Papaverine hydrochloride
Artikelnummer: CDX-P0164-G025
White powder. Soluble in DMSO, ethanol or dimethylformamide. Alkaloid antispasmodic drug that most usually treats visceral spasm or vasospasm. It has also been used in the treatment of erectile dysfunction. Smooth muscle relaxant and vasodilator. Phosphodiesterase PDE10A inhibitor. Show to have antiviral and...
| Schlagworte: | 6,7-Dimethoxy-1-veratrylisoquinoline, NSC 35443, NCI-C56359 |
| Anwendung: | Smooth muscle relaxant, Vasodilator, PDE10A inhibitor |
| CAS | 61-25-6 |
| MW: | 375,9 D |
ab 138,00 €