Zu "K18436" wurden 37 Artikel gefunden!
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PDE7 inhibitor S14
Artikelnummer: TGM-T24606-100mg
Description: PDE7 inhibitor S14 is a cell-permeable PDE7 inhibitor that acts by targeting the cyclic adenosine monophosphate (cAMP)/cAMP-response element-binding protein (CREB) pathway. Target: Others. Smiles: O=C1N(C(=S)NC2=CC=CC=C12)C1=CC=CC=C1. References: Bartolome F, de la Cueva M, Pascual C, Antequera D,...
| Schlagworte: | S14, PDE7 inhibitor-S14 |
| Anwendung: | PDE7 inhibitor |
| CAS | 18741-24-7 |
| MW: | 254.31 D |
ab 1.521,00 €
BRL-50481
Artikelnummer: TGM-T5106-100mg
Description: BRL-50481 is a novel and selective PDE7 inhibitor with IC50 values of 0.15 µM for PDE7A, 12.1 µM for PDE7B, 62 µM for PDE4, and 490 µM for PDE3. Target: PDE. Smiles: CN(C)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O. References: Safavi M, et al. New methods for the discovery and synthesis of PDE7 inhibitors as new...
| Anwendung: | PDE7 inhibitor |
| CAS | 433695-36-4 |
| MW: | 244.27 D |
ab 52,00 €
Theophylline-d6
Artikelnummer: TGM-T71329-1mg
Description: Theophylline-d6 is intended for use as an internal standard for the quantification of theophylline by GC- or LC-MS. Theophylline is an inhibitor of phosphodiesterase. It is also an adenosine A1 and A2 receptor antagonist. Theophylline induces relaxation of isolated cat bronchial smooth muscle segments...
| Anwendung: | GC-MS, LC-MS, quantification, internal standard, PDE inhibitor |
| CAS | 117490-39-8 |
| MW: | 186.2 D |
ab 178,00 €
PDE7A, active human recombinant protein
Artikelnummer: BPS-60070
Active human PDE7A1 GenBank Accession No. NM_002603), (a.a. 121-end) with N-terminal GST tag, MW=66 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
| Schlagworte: | HCP1, TM22, High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 66 kD |
685,00 €
Theophylline
Artikelnummer: Cay23760-25
Theophylline is a methylxanthine alkaloid that is a competitive inhibitor of phosphodiesterase (PDE, Ki = 100 µM). It is also a non-selective antagonist of adenosine A receptors (Ki = 14 µM for A1 and A2). Theophylline induces relaxation of feline bronchiole smooth muscle precontracted with acetylcholine (EC40 = 117...
| Schlagworte: | 1,3-Dimethylxanthine, NSC 2066, 3,9-dihydro-1,3-dimethyl-1H-purine-2,6-dione |
| Anwendung: | PDE inhibitor |
| CAS | 58-55-9 |
| MW: | 180.2 D |
31,00 €
BRL 50481
Artikelnummer: Cay16899-5
BRL 50481 is a potent, selective inhibitor of phosphodiesterase (PDE) 7, inhibiting human recombinant PDE7A1 with a Ki value of 180 nM. It is much less effective against PDE3 and PDE4 and is without effect against PDE1B, PDE1C, PDE2, and PDE5. Through its effects on PDE7A1, BRL 50481 enhances the inhibitory effects...
| Schlagworte: | N,N,2-trimethyl-5-nitro-benzenesulfonamide |
| Anwendung: | PDE7 inhibitor |
| CAS | 433695-36-4 |
| MW: | 244.3 D |
ab 61,00 €
PDE7B, active human recombinant protein
Artikelnummer: BPS-60071
Active human PDE7B GenBank Accession No. NM_018945), (a.a. 107-end) with N-terminal GST tag, MW=66 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
| Schlagworte: | cAMP-specific 3',5'-cyclic phosphodiesterase 7B, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 66 kD |
685,00 €
Anti-PDE7A
Artikelnummer: ARG10807.50
Protein function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction. [The UniProt Consortium]
| Schlagworte: | Anti-HCP1, Anti-TM22, Anti-PDE7A, EC=3.1.4.53, Anti-High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
| Anwendung: | ELISA, IHC (paraffin), IP, WB, DB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
608,00 €
Anti-PDE7B
Artikelnummer: ARG10808.50
Protein function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain. [The UniProt Consortium]
| Schlagworte: | Anti-PDE7B, EC=3.1.4.53, Anti-cAMP-specific 3',5'-cyclic phosphodiesterase 7B |
| Anwendung: | IF, ELISA, ICC, IF, IHC (paraffin), IP, WB, DB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
608,00 €
PDE7A, Active Mouse Recombinant Protein
Artikelnummer: BPS-60072
Mouse PDE7A (GenBank Accession No. NM_001122759), a.a. 147-482(end), with N-terminal GST-tag, MW=65 kDa, expressed in a Baculovirus-infected Sf9 cell expression system. 1 unit is defined as the amount of enzyme that wi
| Schlagworte: | HCP1, TM22, High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 65 kD |
685,00 €
PDE7B, Active Mouse Recombinant Protein
Artikelnummer: BPS-60073
Mouse PDE7B (GenBank Accession No. NM_013875), a.a. 108-446(end), with N-terminal GST-tag, MW=65 kDa, expressed in a Baculovirus-infected Sf9 cell expression system. Assay condition: 10 mM Tris-HCl, pH 7.4, 10 mM MgCl2,
| Schlagworte: | cAMP-specific 3',5'-cyclic phosphodiesterase 7B, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 65 kD |
685,00 €
PDE7A, active rat recombinant protein, N-terminal GST tag
Artikelnummer: BPS-60074
Rat PDE7A (GenBank Accession No. NM_031080), amino acids 147-482(end), with N-terminal GST-tag, MW=65 kDa, expressed in a Baculovirus-infected Sf9 cell expression system. Specific Activity is 354 pmol/min/µg.
| Schlagworte: | Phosphodiesterase, |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | Baculovirus |
| Ursprungsart: | rat |
| MW: | 65 kD |
685,00 €