Zu "K17834" wurden 51 Artikel gefunden!
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Anti-CGAS
Artikelnummer: ATA-HPA031701.100
Polyclonal Antibody against Human CGAS, Gene description: cyclic GMP-AMP synthase, Alternative Gene Names: C6orf150, h-cGAS, MB21D1, Validated applications: ICC, Uniprot ID: Q8N884, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C. Protein function: Nucleotidyltransferase that...
| Schlagworte: | Anti-cGAS, Anti-h-cGAS, Anti-cGAMP synthase, Anti-2'3'-cGAMP synthase, Anti-Cyclic GMP-AMP synthase, Anti-Mab-21... |
| Anwendung: | ICC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
477,00 €
2'3'-cGAMP (sodium salt)
Artikelnummer: Cay19887-500
2'3'-cGAMP is a second messenger produced from ATP and GTP by cGMP-AMP synthase (cGAS) in the cytoplasm of mammalian cells in response to the presence of DNA. It contains a non-canonical 2'5'-phosphodiester bond and binds tightly to the adapter protein STING (stimulator of interferon genes) with a Kd value of 3.79...
| Schlagworte: | 2'-3'-Cyclic GMP-AMP, Guanosine-Adenosine 2',3'-cyclic monophosphate, adenylyl-(3'->5')-2'-guanylic acid, cyclic... |
| Anwendung: | Second messenger |
| MW: | 718.4 D |
ab 271,00 €
PF-06928215
Artikelnummer: TGM-T12432-100mg
Description: PF-06928215 is an inhibitor of cGAS (cyclic GMP-AMP Synthase) (IC50 of 4.9 µ?). Target: cGAS. Smiles: OC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1cnn2c(O)cc(nc12)-c1ccccc1. References: Hall J, et al. Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay....
| Anwendung: | cGAS inhibitor |
| CAS | 2378173-15-8 |
| MW: | 380.4 D |
ab 77,00 €
2'2'-cGAMP (sodium salt)
Artikelnummer: TGM-T35654-1mg
Description: 2'2'-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds. It binds to the adapter protein stimulator of interferon genes , which is a component of the innate immune response that activates the type I interferon pathway when bound to cyclic dinucleotides....
| Anwendung: | Second messenger |
| CAS | 1465774-27-9 |
| MW: | 674.417 D |
ab 1.050,00 €
CU-32
Artikelnummer: TGM-T38328-10mg
Description: CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS, IC50= 0.45 µM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. It is also selective...
| Anwendung: | cGAS inhibitor |
| CAS | 2400954-16-5 |
| MW: | 371.13 D |
ab 198,00 €
CU-76
Artikelnummer: TGM-T38329-5mg
Description: CU-76 is an inhibitor of cyclic GMP-AMP synthase (cGAS, IC50= 0.24 µM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. CU-76 decreases IFN-stimulatory...
| Anwendung: | cGAS inhibitor |
| CAS | 2400954-58-5 |
| MW: | 407.11 D |
709,00 €
RU.521
Artikelnummer: TGM-T5486-100mg
Description: RU.521 (RU3205217) is a potent dsDNA inhibitor (IC50 : 700 nM), inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS. Target: DNA, cGAS. Smiles: Cc1nn(c(O)c1C1OC(=O)c2ccccc12)-c1nc2ccc(Cl)c(Cl)c2[nH]1. References: Vincent J, et al. Small molecule inhibition of cGAS reduces interferon...
| Schlagworte: | RU320521 |
| Anwendung: | cGAS inhibitor |
| CAS | 2262452-06-0 |
| MW: | 415.23 D |
ab 42,00 €
CGAS Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-01166-100ug
Description: CGAS Protein, Human, Recombinant (His) is expressed in E. coli.
| Schlagworte: | Mab-21 domain-containing protein 1, C6orf150, h-cGAS, 2'3'-cGAMP synthase, MB21D1, CGAS, cGAMP synthase, Cyclic GMP-AMP... |
| MW: | 48.3 kD |
ab 198,00 €
Cyclic GMP-AMP synthase (CGAS), partial, human, recombinant
Artikelnummer: CSB-EP822726HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 161-522aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-SUMO-tagged. Target Protein Sequence: GASKLRAVLE KLKLSRDDIS TAAGMVKGVV DHLLLRLKCD SAFRGVGLLN TGSYYEHVKI SAPNEFDVMF KLEVPRIQLE EYSNTRAYYF VKFKRNPKEN PLSQFLEGEI LSASKMLSKF RKIIKEEIND...
| Schlagworte: | cGAS, h-cGAS, cGAMP synthase, 2'3'-cGAMP synthase, Cyclic GMP-AMP synthase, Mab-21 domain-containing protein 1,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 58.3 kD |
ab 219,00 €
Cyclic GMP-AMP synthase (CGAS), partial, human, recombinant
Artikelnummer: CSB-EP822726HUa0.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 161-522aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: GASKLRAVLE KLKLSRDDIS TAAGMVKGVV DHLLLRLKCD SAFRGVGLLN TGSYYEHVKI SAPNEFDVMF KLEVPRIQLE EYSNTRAYYF VKFKRNPKEN PLSQFLEGEI LSASKMLSKF RKIIKEEIND IKDTDVIMKR...
| Schlagworte: | cGAS, h-cGAS, cGAMP synthase, 2'3'-cGAMP synthase, Cyclic GMP-AMP synthase, Mab-21 domain-containing protein 1,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 48.3 kD |
ab 219,00 €
cGAS (human, recombinant)
Artikelnummer: Cay22810-100
Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a nucleotidyltransferase located in the cytosol that acts as a cytosolic DNA sensor to detect foreign DNA from microbial pathogens as part of the innate immune response. Upon binding to cytosolic DNA, cGAS produces the cyclic dinucleotide second messenger cGAMP, which...
| Schlagworte: | cGAS, cGAS, h-cGAS, h-cGAS, cGAMP synthase, cGAMP synthase, 2'3'-cGAMP synthase, 2'3'-cGAMP synthase, Cyclic GMP-AMP... |
| Anwendung: | Cell based assays, ELISA, EPR/ESR, enzyme activity, FC, HTS, IF, IP, MS, Sample Preparation, WB |
| Exprimiert in: | E.coli |
826,00 €
CU-76
Artikelnummer: Cay31030-1
CU-76 is an inhibitor of cyclic GMP-AMP synthase (cGAS, IC50 = 0.24 µM). It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 (IRF3, Cay-22811) in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. CU-76 decreases...
| Schlagworte: | methyl 4-amino-6-((3,5-difluoro-4-iodophenyl)amino)-1,3,5-triazine-2-carboxylate |
| Anwendung: | cGAS inhibitor |
| CAS | 2400954-58-5 |
| MW: | 407.1 D |
ab 111,00 €