Zu "K17719" wurden 40 Artikel gefunden!
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Hydroxy bosentan
Artikelnummer: TGM-T19360-1mg
Description: Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver, assisting BOS pharmacologically with 10%-20% activity retention. Target: Others. Smiles: O=S(=O)(NC=1N=C(N=C(OCCO)C1OC=2C=CC=CC2OC)C3=NC=CC=N3)C4=CC=C(C=C4)C(C)(C)CO....
| Schlagworte: | Ro 48-5033 |
| Anwendung: | Active metabolite, endothelin receptor antagonist |
| CAS | 253688-60-7 |
| MW: | 567.61 D |
ab 287,00 €
Colchicoside
Artikelnummer: TGM-T36115-100mg
Description: Colchicoside (3-Demethylcolchicine glucoside) is extracted from Gloriosa superba and shows efficacy in a murine model of pancreatic adenocarcinoma. Target: Others. Smiles: COC1=C(OC)C2=C(CC[C@H](NC(C)=O)C3=CC(=O)C(OC)=CC=C23)C=C1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O. References: Capistrano I R, et...
| Schlagworte: | 3-Demethylcolchicine glucoside |
| Anwendung: | 3-demethylcolchicine glycoside |
| CAS | 477-29-2 |
| MW: | 547.55 D |
ab 72,00 €
Celecoxib Carboxylic Acid
Artikelnummer: TGM-T36187-10mg
Description: Celecoxib carboxylic acid is an inactive metabolite of the COX-2 inhibitor celecoxib .1,2It is formed from celecoxib primarily by the cytochrome P450 (CYP) isoform CYP2C9. Target: Others. Smiles: NS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1ccc(cc1)C(O)=O)C(F)(F)F. References: Liu, H., Huang, X., Shen, J., et...
| Anwendung: | Inactive celecoxib metabolite |
| CAS | 170571-01-4 |
| MW: | 411.36 D |
ab 264,00 €
trans-carboxy Glimepiride
Artikelnummer: TGM-T35640-1mg
Description: trans-carboxy Glimepiride is a metabolite of the sulfonylurea glimepiride .1It is formed from glimepiride in a two-step process mediated by the cytochrome P450 (CYP) isoform CYP2C9 and cytosolic enzymes. Target: Others. Smiles: CCC1=C(C)CN(C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)N[C@H]2CC[C@@H](CC2)C(O)=O)C1=O...
| Anwendung: | Glimepiride metabolite |
| CAS | 1217739-04-2 |
| MW: | 520.6 D |
524,00 €
trans-hydroxy Glimepiride
Artikelnummer: TGM-T35641-1mg
Description: trans-Hydroxy Glimepiride is an active metabolite of the sulfonylurea glimepiride, formed primarily in the liver by the cytochrome P450 (CYP) isoform CYP2C9. Target: Others. Smiles: CCC1=C(C)CN(C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)N[C@H]2CC[C@H](CO)CC2)C1=O ,...
| Anwendung: | Glimepiride active metabolite |
| CAS | 600177-94-4 |
| MW: | 506.62 D |
822,00 €
(R)-Mephenytoin
Artikelnummer: TGM-T36839-10mg
Description: (R)-Mephenytoin ((-)-Mephenytoin) is the the R-enantiomer of Mephenytoin which is an anticonvulsant agent. Target: Others. Smiles: CC[C@@]1(NC(=O)N(C)C1=O)c1ccccc1. References: Meier, U.T., Kronbach, T., and Meyer, U.A. Assay of mephenytoin metabolism in human liver microsomes by high-performance liquid...
| Schlagworte: | R-Mephenytoin, (R)-Mephenytoin, (-)-Mephenytoin |
| Anwendung: | Enantiomer, CYP2C9 substrate |
| CAS | 71140-51-7 |
| MW: | 218.25 D |
ab 31,00 €
Linderane
Artikelnummer: TGM-T6S1894-100mg
Description: 1. Linderane was characterized as a mechanism-based inactivator of CYP2C9. Target: P450. Smiles: Cc1coc2C\C(C)=C/CC[C@]34O[C@@H]3[C@@H](OC4=O)c12. References: Determination of linderane in root tuber of Lindera aggregata by HPLC,
| Anwendung: | CYP2C9 inhibitor |
| CAS | 13476-25-0 |
| MW: | 260.29 D |
ab 42,00 €
CYP2C9 Protein, Human, Recombinant (His & Myc)
Artikelnummer: TGM-TMPH-01186-100ug
Description: CYP2C9 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
| Schlagworte: | Cytochrome P450 MP-4, Cytochrome P450 MP-8, S-mephenytoin 4-hydroxylase, (R)-limonene 6-monooxygenase, CYP2C10, Cytochrome... |
| MW: | 25.4 kD |
ab 281,00 €
Cytochrome P450 2C9 (CYP2C9), human, recombinant
Artikelnummer: CSB-EP006419HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-162aa. Protein Length: Full Length of Isoform 2. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: MDSLVVLVLC LSCLLLLSLW RQSSGRGKLP PGPTPLPVIG NILQIGIKDI SKSLTNLSKV YGPVFTLYFG LKPIVVLHGY EAVKEALIDL GEEFSGRGIF...
| Schlagworte: | CYPIIC9, Cytochrome P-450MP, Cytochrome P450 2C9, Cytochrome P450 MP-8, Cytochrome P450 PB-1, Cytochrome P450 MP-4,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 25.4 kD |
ab 292,00 €
Anti-CYP2C9
Artikelnummer: CSB-PA088788.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: CYP2C9. Antigen Species: Human
| Schlagworte: | Anti-CYPIIC9, Anti-Cytochrome P-450MP, Anti-Cytochrome P450 2C9, Anti-Cytochrome P450 MP-4, Anti-Cytochrome P450 MP-8,... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 167,00 €
Anti-CYP2C9
Artikelnummer: CSB-PA106326.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: CYP2C9. Antigen Species: Human
| Schlagworte: | Anti-CYPIIC9, Anti-Cytochrome P-450MP, Anti-Cytochrome P450 2C9, Anti-Cytochrome P450 MP-4, Anti-Cytochrome P450 MP-8,... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 167,00 €
Sulfaphenazole
Artikelnummer: Cay14844-250
CYP2C9 is a major cytochrome P450 enzyme that is involved in the metabolic clearance of various therapeutic agents. Disruption of this enzyme's activity can lead to adverse drug reactions. Sulfaphenazole is an inhibitor of CYP2C9 (Ki = 0.3 µM) that demonstrates at least 100-fold selectivity over other CYP450...
| Schlagworte: | Depocid, Depotsulfonamide, Plisulfan, Raziosulfa, 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)-benzenesulfonamide |
| Anwendung: | CYP2C9 inhibitor |
| CAS | 526-08-9 |
| MW: | 314.4 D |
ab 161,00 €