Zu "K17690" wurden 22 Artikel gefunden!
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4beta-hydroxy Cholesterol
Artikelnummer: TGM-T21530-1mg
Description: 4beta-hydroxy Cholesterol is a useful organic compound for research related to life sciences. The catalog number is T21530 and the CAS number is 17320-10-4. Target: Others. Smiles: CC(C)CCC[C@@H](C)[C@H]1CCC2C3CC=C4[C@@H](O)[C@@H](O)CC[C@]4(C)C3CC[C@]12C
| Anwendung: | Oxysterol, CYP3A4/5 metabolite |
| CAS | 17320-10-4 |
| MW: | 402.653 D |
ab 93,00 €
Dehydro Nifedipine
Artikelnummer: TGM-T36665-10mg
Description: Dehydro Nifedipine (BAY-b 4759) is the main metabolite of nifedipine in human plasma. Dehydro Nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 µM. Nifedipine is a calcium channel blocker used in the treatment of hypertension and angina. Dehydronifedipine is formed when it is...
| Schlagworte: | BAY-b 4759 |
| Anwendung: | Active nifedipine metabolite |
| CAS | 67035-22-7 |
| MW: | 344.32 D |
ab 49,00 €
Desethoxy Quetiapine hydrochloride
Artikelnummer: TGM-T84947-10mg
Description: Desethoxy quetiapine, an active metabolite of the atypical antipsychotic quetiapine, primarily forms through the action of the cytochrome P450 (CYP) isoform CYP3A5. This compound binds to dopamine D2 receptors with an IC50 value of 1,330 nM. In vivo, desethoxy quetiapine at dosages of 20 and 40 mg/kg...
| Schlagworte: | O-Desalkylquetiapine |
| Anwendung: | Quetiapine active metabolite |
| CAS | 329218-14-6 |
| MW: | 412.38 D |
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Cytochrome P450 3A5 (CYP3A5), human, recombinant
Artikelnummer: CSB-EP006441HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-502aa. Protein Length: Full Length. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: MDLIPNLAVE TWLLLAVSLV LLYLYGTRTH GLFKRLGIPG PTPLPLLGNV LSYRQGLWKF DTECYKKYGK MWGTYEGQLP VLAITDPDVI RTVLVKECYS VFTNRRSLGP VGFMKSAISL AEDEEWKRIR...
| Schlagworte: | CYPIIIA5, Cytochrome P450 3A5, Cytochrome P450-PCN3, Recombinant Human Cytochrome P450 3A5 (CYP3A5) |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 61.2 kD |
ab 292,00 €
4beta-hydroxy Cholesterol
Artikelnummer: Cay19518-1
4beta-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation. It is formed from cholesterol by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5. 4beta-hydroxy Cholesterol has an unusually long half-life in plasma (~60...
| Schlagworte: | cholest-5-ene-3beta,4beta-diol |
| Anwendung: | Oxysterol, CYP3A4/5 metabolite |
| CAS | 17320-10-4 |
| MW: | 402.7 D |
ab 52,00 €
Dehydro Nifedipine
Artikelnummer: Cay23229-1
Dehydro nifedipine is an active metabolite of nifedipine (Cay-11106), a calcium channel blocker present in formulations used to treat hypertension and angina. Dehydro nifedipine is formed when nifedipine is metabolized by the cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5. Dehydro nifedipine inhibits glucose uptake...
| Schlagworte: | BAY-b 4759, 2,6-dimethyl-4-(2-nitrophenyl)-3,5-dimethyl ester 3,5-pyridinedicarboxylic acid |
| Anwendung: | Active nifedipine metabolite |
| CAS | 67035-22-7 |
| MW: | 344.3 D |
ab 61,00 €
Human CYP3A5 / Cytochrome P450 3A5 ELISA Kit
Artikelnummer: G-HUFI01147.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
641,00 €
N-Desethyl Vardenafil
Artikelnummer: Cay9001800-500
N-Desethyl vardenafil is a metabolite of vardenafil (Cay-14930), a phosphodiesterase 5 inhibitor, that is formed by the action of cytochrome P450 (CYP)3A4 and CYP3A5.Formal Name: 2-[2-ethoxy-5-(1-piperazinylsulfonyl)phenyl]-5-methyl-7-propyl-imidazo[5,1-f][1,2,4]triazin-4(1H)-one. CAS Number: 448184-46-1. Molecular...
| Schlagworte: | 2-[2-ethoxy-5-(1-piperazinylsulfonyl)phenyl]-5-methyl-7-propyl-imidazo[5,1-f][1,2,4]triazin-4(1H)-one |
| Anwendung: | Vardenafil metabolite |
| CAS | 448184-46-1 |
| MW: | 460.6 D |
ab 44,00 €
Cobicistat
Artikelnummer: Cay23433-25
Cobicistat is an inhibitor of the cytochrome P450 (CYP) isomer CYP3A (IC50s = 30-285 nM for CYP3A metabolism of various HIV protease inhibitors). It is selective for CYP3A over other CYP isomers (IC50 = >25 µM for CYP1A2, 2C8, 2C9, and 2C19). Cobicistat does not inhibit HIV-1 protease (IC50 = >30 µM) or affect HIV...
| Schlagworte: | GS-9350,... |
| Anwendung: | CYP3A inhibitor |
| CAS | 1004316-88-4 |
| MW: | 776 D |
ab 52,00 €
4beta-hydroxy Cholesterol-d7
Artikelnummer: Cay25971-1
4beta-hydroxy Cholesterol-d7 is intended for use as an internal standard for the quantification of 4beta-hydroxy cholesterol (Cay-19518) by GC- or LC-MS. 4beta-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation. It is...
| Schlagworte: | cholest-5-ene-25,26,26,26,27,27,27-d7-3beta,4beta-diol |
| Anwendung: | Oxysterol, CYP3A4/5 metabolite, GC-MS, LC-MS, internal standard |
| CAS | 1246302-80-6 |
| MW: | 409.7 D |
ab 259,00 €
16alpha-hydroxy Prednisolone
Artikelnummer: Cay27169-1
16alpha-hydroxy Prednisolone is a metabolite of 22(R)-budesonide. It is formed from 22(R)-budesonide by the cytochrome P450 (CYP) isoform CYP3A in human liver microsomesFormal Name: (11beta,16alpha)-11,16,17,21-tetrahydroxy-pregna-1,4-diene-3,20-dione. CAS Number: 13951-70-7. Molecular Formula: C21H28O6. Formula...
| Schlagworte: | (11beta,16alpha)-11,16,17,21-tetrahydroxy-pregna-1,4-diene-3,20-dione |
| Anwendung: | 22(R)-Budesonide metabolite |
| CAS | 13951-70-7 |
| MW: | 376.4 D |
ab 44,00 €
Desethoxy Quetiapine (hydrochloride)
Artikelnummer: Cay35410-10
Desethoxy quetiapine is an active metabolite of the atypical antipsychotic quetiapine (Cay-14152). It is formed from quetiapine primarily by the cytochrome P450 (CYP) isoform CYP3A5 and binds to dopamine D2 receptors (IC50 = 1,330 nM). Desethoxy quetiapine (20 and 40 mg/kg) reduces climbing induced by the dopamine...
| Schlagworte: | O-Desalkylquetiapine, 4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazineethanol, dihydrochloride |
| Anwendung: | Quetiapine active metabolite |
| CAS | 329218-14-6 |
| MW: | 412.4 D |
ab 230,00 €