Zu "K17689" wurden 120 Artikel gefunden!
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4-hydroxy Alprazolam
Artikelnummer: Cay15878-1
Alprazolam is a benzodiazepine with anxiolytic and sedative actions. 4-Hydroxyalprazolam is a major metabolite of alprazolam, produced by the actions of cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5. It may be detected in serum or, in a glucuronidated form, in urine. Alternatively, 4-hydroxyalprazolam can be...
| Schlagworte: | 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-ol |
| Anwendung: | Alprazolam metabolite |
| CAS | 30896-57-2 |
| MW: | 324.8 D |
ab 60,00 €
Axitinib sulfoxide
Artikelnummer: TGM-T21129-1mg
Description: Axitinib sulfoxide is a major metabolite of Axitinib, which is a VEGFR tyrosine kinase inhibitor and may be useful in cancer therapy. Target: Others. Smiles: C(=C/C1=CC=CC=N1)\C=2C=3C(=CC(S(=O)C4=C(C(NC)=O)C=CC=C4)=CC3)NN2. References: Slobbe P, Poot AJ, Haumann R, Schuit RC, Windhorst AD, van Dongen...
| Schlagworte: | PF-03482595, AG-028458, Axitinib metabolite M12 |
| Anwendung: | Major inactive metabolite |
| CAS | 1347304-18-0 |
| MW: | 402.47 D |
ab 151,00 €
PF-4981517
Artikelnummer: TGM-T21548-1mg
Description: PF-4981517 (CYP3cide) is a efficient, specific and time-dependent inhibitor of cytochrome P4503A4 (CYP3A4). The IC 50 values for CYP3A activity are 0.03 µM,17 µM, and 71 µM for CYP3A4, CYP3A5, and CYP3A7, respectively. PF-4981517 is able to be used to distinguish the contributions of CYP3A4 versus...
| Schlagworte: | CYP3cide |
| Anwendung: | CYP3A4 inhibitor |
| CAS | 1390637-82-7 |
| MW: | 456.59 D |
ab 41,00 €
21-hydroxy Eplerenone
Artikelnummer: TGM-T36129-1mg
Description: 21-hydroxy Eplerenone is a major metabolite of the mineralocorticoid receptor antagonist eplerenone . It is formed from eplerenone by the cytochrome P450 (CYP) isoform CYP3A4. Target: Others. Smiles:...
| Anwendung: | Major eplerenone metabolite |
| CAS | 334678-67-0 |
| MW: | 430.497 D |
821,00 €
N-Desethyl Vardenafil
Artikelnummer: TGM-T35714-1mg
Description: N-Desethyl vardenafil is a metabolite of vardenafil , a phosphodiesterase 5 inhibitor, that is formed by the action of cytochrome P450 (CYP)3A4 and CYP3A5. Target: Others. Smiles: O=C1N=C(NN2C(=NC(=C12)C)CCC)C=3C=C(C=CC3OCC)S(=O)(=O)N4CCNCC4
| Anwendung: | Vardenafil metabolite |
| CAS | 448184-46-1 |
| MW: | 460.55 D |
ab 77,00 €
N-desmethyl Eletriptan
Artikelnummer: TGM-T35715-1mg
Description: N-Desmethyl Eletriptan, a metabolite of eletriptan, is primarily formed from eletriptan by the cytochrome P450 (CYP) isoform CYP3A4 in human liver microsomes. Target: Others. Smiles: O=S(=O)(CCc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1)c1ccccc1. References: Evans, D.C., O'Connor, D., Lake, B.G., et al.Eletriptan...
| Anwendung: | Eletriptan metabolite |
| CAS | 153525-55-4 |
| MW: | 368.5 D |
262,00 €
4-hydroxy Atorvastatin (calcium salt)
Artikelnummer: TGM-T35724-1mg
Description: 4-hydroxy Atorvastatin is a metabolite of atorvastatin , an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias. Atorvastatin is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form 4-hydroxy atorvastatin. Target:...
| Anwendung: | Atorvastatin metabolite |
| CAS | 265989-44-4 |
| MW: | 1191.393 D |
ab 193,00 €
Monocrotaline
Artikelnummer: TGM-T2803-100mg
Description: Monocrotaline (Crotaline) is a pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary...
| Schlagworte: | Crotaline |
| Anwendung: | Pulmonary hypertension inducer |
| CAS | 315-22-0 |
| MW: | 325.36 D |
ab 41,00 €
Imidafenacin Metabolite M4
Artikelnummer: TGM-T36662-1mg
Description: Imidafenacin metabolite M4 is a metabolite of the muscarinic acetylcholine receptor antagonist imidafenacin.1It is formed from imidafenacin by the cytochrome P450 (CYP) isoform CYP3A4. Target: Others. Smiles: NC(=O)C(=O)NCCC(C(N)=O)(c1ccccc1)c1ccccc1. References: Kanayama, N., Kanari, C., Masuda, Y., et...
| Schlagworte: | Imidafenacin Metabolite M4 |
| Anwendung: | Imidafenacin metabolite |
| CAS | 503598-17-2 |
| MW: | 325.368 D |
ab 269,00 €
Voriconazole N-oxide
Artikelnummer: TGM-T37796-1mg
Description: Voriconazole N-oxide is a major metabolite of the triazole antifungal voriconazole . It is formed via oxidation of voriconazole by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C19. Target: Others. Smiles: C[C@@H](c1ncn(=O)cc1F)[C@](O)(Cn1cncn1)c1ccc(F)cc1F
| Anwendung: | Major voriconazole metabolite |
| CAS | 618109-05-0 |
| MW: | 365.316 D |
ab 388,00 €
rac-Desethyl Oxybutynin (hydrochloride)
Artikelnummer: TGM-T37801-1mg
Description: rac-Desethyl oxybutynin is an active metabolite of the muscarinic acetylcholine receptor (mAChR) antagonist oxybutynin .1,2,3rac-Desethyl oxybutynin is formed from oxybutynin by the cytochrome P450 (CYP) isoform CYP3A4.2It binds to mAChRs in isolated rat bladder, submaxillary gland, heart, and colon...
| Anwendung: | Oxybutynin active metabolite |
| CAS | 81039-77-2 |
| MW: | 365.89 D |
ab 193,00 €
6beta-hydroxy Eplerenone
Artikelnummer: TGM-T37064-1mg
Description: 6beta-hydroxy Eplerenone is a major metabolite of the mineralocorticoid receptor antagonist eplerenone .1 It is formed from eplerenone by the cytochrome P450 (CYP) isoform CYP3A4. Target: Others. Smiles:...
| Anwendung: | Major metabolite |
| CAS | 209253-80-5 |
| MW: | 430.497 D |
1.098,00 €