Zu "K17388" wurden 73 Artikel gefunden!
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Y27632 dihydrochloride
Artikelnummer: LKT-Y1000.25
Y27632 is a selective inhibitor of Rho-associated protein kinase (ROCK), Y27632 binds to the catalytic site of ROCK, preventing binding of Ras-related GTPase Rho A, which is involved in actin cytoskeleton reorganization, cell adhesion, and cell migration. Y27632 inhibits downstream endothelin and TGF- -related...
| Anwendung: | ROCK inhibitor |
| CAS | 129830-38-2 |
| MW: | 320.26 D |
ab 128,00 €
GSK269962A
Artikelnummer: TGM-T3518-100mg
Description: GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively. Target: ROCK, S6 Kinase. Smiles: CCn1c(nc2cnc(Oc3cccc(NC(=O)c4ccc(OCCN5CCOCC5)cc4)c3)cc12)-c1nonc1N. References: Doe C, et al. J Pharmacol Exp...
| Schlagworte: | GSK269962B, GSK269962A HCl, GSK 269962 |
| Anwendung: | Selective ROCK inhibitor |
| CAS | 850664-21-0 |
| MW: | 570.6 D |
ab 37,00 €
CAY10746
Artikelnummer: TGM-T36196-100mg
Description: CAY10746 is a selective Rho kinase (ROCK) inhibitor, targeting ROCK I and ROCK II with IC50 values of 0.014 µM and 0.003 µM, respectively. CAY10746 can be employed in the study of diabetic retinopathy. Target: ROCK. Smiles: CN(C)c1ccc(cc1)C(=O)Nc1cccc(NC(=O)COc2ccc3c(c2)occc3=O)c1. References: Zhao L,...
| Anwendung: | ROCK-I inhibitor, ROCK-II inhibitor |
| CAS | 2247240-76-0 |
| MW: | 457.48 D |
ab 48,00 €
Belumosudil
Artikelnummer: TGM-T6867-100mg
Description: Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM). Target: ROCK. Smiles: CC(C)NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1. References: Lee JH, et al. Ann Clin Transl Neurol. 2014, 1(1), 2-14.
| Schlagworte: | KD025, Rezurock, ROCK inhibitor, SLx-2119 |
| Anwendung: | Targets Rho-associated protein kinase 2 [EC:2.7.11.39] (ROCK2) |
| CAS | 911417-87-3 |
| MW: | 452.51 D |
ab 42,00 €
Zelasudil
Artikelnummer: TGM-T69665-10mg
Description: Zelasudil (RXC007) is a Rho-related (ROCK) kinase inhibitor for the study of idiopathic pulmonary fibrosis and inflammation. Target: ROCK. Smiles: O=C(NCC(F)F)C=1C=CC(=CC1)C=2N=C(NC3=CC=C4NN=CC4=C3C5CC5)N(N2)C. References: Lee E, et al. Selective ROCK2 inhibition for treatment of edema and associated...
| Schlagworte: | RXC007 |
| Anwendung: | ROCK2 inhibitor |
| CAS | 2365193-22-0 |
| MW: | 437.445 D |
ab 320,00 €
Y-33075
Artikelnummer: TGM-T13384-100mg
Description: Y-33075, a selective inhibitor of ROCK derived from Y-27632, exhibits greater potency than Y-27632 with an IC50 of 3.6 nM. Target: PKC. Smiles: C[C@@H](N)c1ccc(cc1)C(=O)Nc1ccnc2[nH]ccc12. References: Hideki Tokushige, et al. Effects of Topical Administration of Y-39983, a Selective Rho-Associated...
| Schlagworte: | Y 39983 |
| Anwendung: | ROCK2 inhibitor |
| CAS | 199433-58-4 |
| MW: | 280.32 D |
ab 112,00 €
ROCK inhibitor-2
Artikelnummer: TGM-T12746-100mg
Description: ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2, with IC50 values of 17 nM and 2 nM, respectively. Target: ROCK. Smiles: COc1cccc(c1)[C@@H](C)NC(=O)c1ccc(cc1)-c1ccncc1. References: Hobson AD, et al. Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based...
| Anwendung: | ROCK inhibitor |
| CAS | 1127308-52-4 |
| MW: | 332.4 D |
ab 60,00 €
Chroman 1
Artikelnummer: TGM-T14960-100mg
Description: Chroman 1 is a potent inhibitor of ROCK1 (IC50 = 52 pM) and ROCK2 (IC50 = 1 pM). Target: ROCK. Smiles: COc1ccc2OC[C@H](Cc2c1)C(=O)Nc1ccc(cc1OCCN(C)C)-c1cn[nH]c1. References: Yen Ting Chen, et al. Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors. Med.Chem.Commun., 2011, 2, 73-75.
| Anwendung: | ROCK2 inhibitor |
| CAS | 1273579-40-0 |
| MW: | 436.5 D |
ab 71,00 €
Zelasudil
Artikelnummer: Cay41163-1
Zelasudil is a Rho-associated kinase 2 (ROCK2) inhibitor.Formal Name: 4-[5-[(4-cyclopropyl-1H-indazol-5-yl)amino]-1-methyl-1H-1,2,4-triazol-3-yl]-N-(2,2-difluoroethyl)-benzamide. CAS Number: 2365193-22-0. Synonyms: RXC007. Molecular Formula: C22H21F2N7O. Formula Weight: 437.5. Purity: >98%. Formulation: (Request...
| Schlagworte: | RXC007, 4-[5-[(4-cyclopropyl-1H-indazol-5-yl)amino]-1-methyl-1H-1,2,4-triazol-3-yl]-N-(2,2-difluoroethyl)-benzamide |
| Anwendung: | ROCK2 inhibitor |
| CAS | 2365193-22-0 |
| MW: | 437.5 D |
ab 217,00 €
Anti-ROCK2
Artikelnummer: CSB-PA004018.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-ROCK2, Anti-ROCK-II, Anti-KIAA0619, EC=2.7.11.1, Anti-p164 ROCK-2, Anti-Rho kinase 2, Anti-Rho-associated protein... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat, monkey |
ab 126,00 €
Anti-ROCK2
Artikelnummer: CSB-PA005112.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-ROCK2, Anti-ROCK-II, Anti-KIAA0619, EC=2.7.11.1, Anti-p164 ROCK-2, Anti-Rho kinase 2, Anti-Rho-associated protein... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 126,00 €
Anti-Phospho-ROCK2 (Tyr722)
Artikelnummer: CSB-PA035451.100
Host Species: Rabbit. Isotype: IgG. Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antibodies were produced by immunizing rabbits...
| Schlagworte: | Anti-phospho-ROCK2, Anti-phospho-ROCK-II, Anti-phospho-KIAA0619, EC=2.7.11.1, Anti-phospho-p164 ROCK-2, Anti-phospho-Rho... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
340,00 €